<Cell Stem Cell> 2011.3 Perspective. A Precarious Balance Pluripotency Fac

清风闲云

Kyle M. Loh, and Bing Lim/ k( N6 L* U7 U, O
Understanding the basis of the unrestricted multilineage differentiation potential of pluripotent cells will be of" i* |' t, x& B9 G- _# n- j
developmental and translational consequence. We propose that pluripotency transcription factors are
6 Y3 v8 d3 R- `lineage specifiers that direct commitment to specific fetal lineages. Individual factors bestow the ability to# J8 ^0 B/ |9 z" X& e( M: n5 A
differentiate into particular cell types, and concomitant expression of multiple lineage specifiers within pluripotent1 ]2 k6 B, X3 Z( ^( R0 a
cells enables differentiation into every fetal lineage. Moreover, we speculate that, rather than being an" L2 Z2 r* v4 q* T0 q
intrinsically stable ‘‘ground state,’’ pluripotency is an inherently precarious condition in which rival lineage# d( t, r' d6 z8 I. M) ?
specifiers continually compete to specify differentiation along mutually exclusive lineages.
9 y) ^' d9 D) H" A* x9 G

蝶澈

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红旗

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