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Kyle M. Loh, and Bing Lim
0 s$ q/ d4 G+ `6 O9 qUnderstanding the basis of the unrestricted multilineage differentiation potential of pluripotent cells will be of
' M+ D |; O+ S5 t3 udevelopmental and translational consequence. We propose that pluripotency transcription factors are. J+ ?: P8 c3 I* s
lineage specifiers that direct commitment to specific fetal lineages. Individual factors bestow the ability to
" C) i" N3 ?6 n( @differentiate into particular cell types, and concomitant expression of multiple lineage specifiers within pluripotent
0 S* `6 q! Q. a0 f0 D. `! tcells enables differentiation into every fetal lineage. Moreover, we speculate that, rather than being an
( Z$ Z+ z7 [+ k- C' @4 T0 `intrinsically stable ‘‘ground state,’’ pluripotency is an inherently precarious condition in which rival lineage
# M- p( U$ a" D5 ]2 L' Q0 `* K/ G; Xspecifiers continually compete to specify differentiation along mutually exclusive lineages.
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发表于 2011-5-5 11:41
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