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Three-dimensional hydrogel scaffolds designed to mimic the extracellular matrix are being created that incorporate biomimetic motifs, such as cell binding sequences, proteolytically degradable crosslinks, and regulatory protein analogs. Surface coatings tuned to resist non-specific protein adsorption and cell adhesion are being explored, which can then be tethered with cell binding and regulatory protein sequences to address fundamental questions in cell biology and tissue engineering. |
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