成骨细胞分化和体内骨形成

botizhou

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lifangamanda

谢谢楼主呢！

lifangamanda

哈哈，花了2个包包下了！以前似乎看到过！

皮搋子

真是一篇挺好的文章，可惜的是lz也没有做介绍，就这样真是明珠蒙尘。
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Strontium Enhances Osteogenic Differentiation of Mesenchymal Stem Cells and In Vivo Bone Formation by Activating Wnt/Catenin Signaling/ T5 @% M* s5 x* |  W6 ]6 j% b
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FAN YANG, DAZHI YANG, JIE TU, QIXIN ZHENG, LINTAO CAI, LIPING WANGa a: r2 Z% B- i; C4 U- k- V
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Research Center for Neural Engineering, Shenzhen Key Laboratory for Neuropsychiatric Modulation,Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China;8 Q7 Q5 j. [* y1 `- d+ y# c
Department of Orthopaedics, Union Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, China;
% J" [% O+ i# z# ]Shenzhen Key Laboratory for Cancer Nanotechnology, Shenzhen Institutes of Advanced Technology,# [! H* {. S& \% x" Z
Chinese Academy of Sciences, Shenzhen, China4 h( b1 d( l/ ]# w. E/ x6 J. L

6 B% \1 {% A2 }' C  y6 d    Strontium ranelate is a newly approved drug that can reduce the risk of vertebral fracture, which is attributed to its dual function in increasing the bone formation and decreasing the bone resorption. Strontium-containing hydroxyapatite was also demonstrated to stimulate the/ \3 F7 ?% s$ r/ \
osteoblast activity and inhibit the osteoclast activity.However, the molecular mechanisms of strontium underly- ing such beneficial effects were still not fully understood.: G5 q+ r5 k* k+ _

, [) r$ G7 Q! E% z- Y   In this study, we investigated the effects of strontium on the osteogenic differentiation of human mesenchymal stem cells (MSCs) and its related mechanism; its osteogenic potential was also evaluated using a calvarial defect model in rats. We found that strontium could enhance
% Y. d" \  R' S' Y2 ?! bthe osteogenic differentiation of the MSCs, with upregulated extracellular matrix (ECM) gene expression and activated Wnt/b-catenin pathway. After transplanting the collagen-strontium-substituted hydroxyapatite scaffold into the bone defect region, histology and computed to mography scanning revealed that in vivo bone formation was significantly enhanced; the quantity of mature and remodeled bone substantially increased and ECM accumulated. Interestingly, strontium induced an increase of bcatenin expression in newly formed bone area. In this
1 W$ N* K( e+ D# n, Zstudy, we showed for the first time that strontium could stimulate the b-catenin expression in vitro and in vivo, which might contribute to the enhanced osteogenic differentiation of MSCs and in vivo bone formation. STEM CELLS 2011;29:981–991
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