成骨细胞分化和体内骨形成

botizhou

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皮搋子

真是一篇挺好的文章，可惜的是lz也没有做介绍，就这样真是明珠蒙尘。6 n( F6 b+ L2 o* _
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Strontium Enhances Osteogenic Differentiation of Mesenchymal Stem Cells and In Vivo Bone Formation by Activating Wnt/Catenin Signaling5 K& R" K. k- t1 S' V# n) R1 z

  G3 E8 x- U6 V& V: t% P; v2 aFAN YANG, DAZHI YANG, JIE TU, QIXIN ZHENG, LINTAO CAI, LIPING WANGa a: C9 C# X6 Q' B; g

. R1 N/ J6 V8 b0 C  `Research Center for Neural Engineering, Shenzhen Key Laboratory for Neuropsychiatric Modulation,Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China;& V0 `( I9 o% l! p
Department of Orthopaedics, Union Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, China;. t& }6 ^% L9 H5 i" }
Shenzhen Key Laboratory for Cancer Nanotechnology, Shenzhen Institutes of Advanced Technology,: ^  {  O$ A5 [. h6 e: V$ S6 h* \4 {
Chinese Academy of Sciences, Shenzhen, China4 o; p+ _4 S3 e' @6 f( M! d& `2 J

' k- U$ o6 H! x7 F( |# ~    Strontium ranelate is a newly approved drug that can reduce the risk of vertebral fracture, which is attributed to its dual function in increasing the bone formation and decreasing the bone resorption. Strontium-containing hydroxyapatite was also demonstrated to stimulate the
! m0 K5 C. S- _osteoblast activity and inhibit the osteoclast activity.However, the molecular mechanisms of strontium underly- ing such beneficial effects were still not fully understood." f7 E9 c8 O, j- ~

7 A9 L; g! Y. f- W; f# z: E   In this study, we investigated the effects of strontium on the osteogenic differentiation of human mesenchymal stem cells (MSCs) and its related mechanism; its osteogenic potential was also evaluated using a calvarial defect model in rats. We found that strontium could enhance
1 I( a" h" S9 A2 R" nthe osteogenic differentiation of the MSCs, with upregulated extracellular matrix (ECM) gene expression and activated Wnt/b-catenin pathway. After transplanting the collagen-strontium-substituted hydroxyapatite scaffold into the bone defect region, histology and computed to mography scanning revealed that in vivo bone formation was significantly enhanced; the quantity of mature and remodeled bone substantially increased and ECM accumulated. Interestingly, strontium induced an increase of bcatenin expression in newly formed bone area. In this0 u# E/ i, `& e" }& P( Y
study, we showed for the first time that strontium could stimulate the b-catenin expression in vitro and in vivo, which might contribute to the enhanced osteogenic differentiation of MSCs and in vivo bone formation. STEM CELLS 2011;29:981–991% K1 H! T0 `, Z8 m/ g  ?& r1 k5 @
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lifangamanda

哈哈，花了2个包包下了！以前似乎看到过！

lifangamanda

谢谢楼主呢！