Review stem cell

bridgeyangfan

Emerging models and paradigms for stem cell ageing   V5 D' \6 ?- m& P
D. Leanne Jones and Thomas A. Rando
# ]* @5 H6 x2 X3 K8 l0 GAgeing is accompanied by a progressive decline in stem cell function, resulting in less effective tissue homeostasis and repair.- }. G. m0 i) f- s
Here we discuss emerging invertebrate models that provide insights into molecular pathways of age-related stem cell dysfunction# C! l$ |4 M1 @' @* l0 m9 J
in mammals, and we present various paradigms of how stem cell functionality changes with age, including impaired self-renewal
- `& g/ x2 Q% ]2 E* eand aberrant differentiation potential., P9 x  x: m( ]1 L, n( _
"Nature cell biology 13(5) 2011"& ~' b; v, e  ~$ l5 P; s, r