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Emerging models and paradigms for stem cell ageing % x. G a; c% R
D. Leanne Jones and Thomas A. Rando! w3 J7 K; Q5 N7 j8 k& |* q H: ~
Ageing is accompanied by a progressive decline in stem cell function, resulting in less effective tissue homeostasis and repair.5 N8 [/ n" p$ H1 K
Here we discuss emerging invertebrate models that provide insights into molecular pathways of age-related stem cell dysfunction
# M$ H _4 H) oin mammals, and we present various paradigms of how stem cell functionality changes with age, including impaired self-renewal
6 E; e) E9 Q$ v' Pand aberrant differentiation potential.
) e. m. M% I) R' n, O. J"Nature cell biology 13(5) 2011"
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发表于 2011-7-11 10:26
