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Emerging models and paradigms for stem cell ageing 2 d) {, i' T- A8 P4 Q. y5 o
D. Leanne Jones and Thomas A. Rando! G* f- \% D" c5 e0 D' D
Ageing is accompanied by a progressive decline in stem cell function, resulting in less effective tissue homeostasis and repair.5 C- G4 D0 |. j i) g) D
Here we discuss emerging invertebrate models that provide insights into molecular pathways of age-related stem cell dysfunction
+ Z0 {) U4 E! L! i2 Rin mammals, and we present various paradigms of how stem cell functionality changes with age, including impaired self-renewal
4 r& P% v: N" r% Uand aberrant differentiation potential. I5 I3 c {) o7 x1 P- m& Y" @3 K* d
"Nature cell biology 13(5) 2011") i3 \3 H2 |) y3 P$ [8 Z- H) E
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发表于 2011-7-11 10:26
