谈谈tet和5-hmC

hongjie88

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$ I' @( N0 }4 T2 B我看最近有好多关于这个的文章啊，貌似是很火  V  O3 ^6 g" d0 ~$ J/ ?
列几个跟大家分享一下/ f5 ?- m- h: V# ?  `+ y( ], C
Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development.Cell Stem Cell. 2011 Aug 5; 9(2): 166-75$ c% x+ ?3 B! e; z( [5 Y
Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development.Cell Res. 2011 Jul 12: h% n% T/ b. i- [% N2 D
Tissue specific distribution and dynamic changes of 5-hydroxymethylcytosine in mammalian genome.J Biol Chem. 2011 May 24
9 j$ W( g. W2 z9 HGenome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells.Nature. 2011 May 8; ! V7 E& u6 D/ L
Genome-wide Regulation of 5hmC, 5mC, and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells.Mol Cell. 2011 Apr 20;
& z( o8 S- R' ]9 T" F3 x0 |Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation.Nature. 2011 Apr 3; ; f0 c" M: A  s) W: D: B6 `
Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells.Genes Dev. 2011 Apr 1; 25(7): 679-84
' S% j& Z' q/ E- m7 @% \Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells.Nature. 2011 Mar 30; . T  R# J8 G* ~- R
Tet1 and tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells.Cell Stem Cell. 2011 Feb 4; 8(2): 200-13
3 d% e' N- u7 T这才半年就有这么多文章。。。
  \& B3 O* Y; e. y7 J6 z3 W, T) p大家感兴趣的交流一下吧
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hongjie88

回复 hongjie88 的帖子, s8 F" p# M" h1 O! \7 V# a

  g9 B& _6 r, X# \5 {2 [* W我这有全文的只有几篇，大家继续补充啊~~

kephort

这是一个很好的话题啊，动物细胞DNA的去甲基化问题不甚别了，貌似现在开始逐渐浮出水面了。
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Tet到底与DNA去甲基化之间有什么关系？在DNA去甲基化过程中如何起到调控作用？目前文献中采用了哪些方法能说明5-hmc是/否为去甲基化的中间状态？欢迎看了这方面的达人列一下啊？2 o# g3 {- s0 g' ~( `
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另外：从方法学上，除了抗5-hmc的抗体可以分析5-hmc外，还有哪些文献报道了相关的分析方法？欢迎大家汇总。

fwyou

好像缺几篇文献吧, J0 B, f; J8 i# F
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Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development.Cell Stem Cell. 2011 Aug 5; 9(2): 166-751 I4 G" ]8 |: V) R9 z. R! t8 P
Genome-wide Regulation of 5hmC, 5mC, and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells.Mol Cell. 2011 Apr 20;
# ]. p2 v3 a$ P# t, XGenome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells.Genes Dev. 2011 Apr 1; 25(7): 679-84* M7 e& c) L% F( k8 _# v
都没有啊% }# n9 I' Q8 R4 M
版主，你有没？
$ r' L; G& F2 N3 z- `& }# y或者群友别人有没》？

yeya

我来上传吧。貌似生化所最近SCIENCE也有发Tet

xlwhzp

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science上最新的两篇文章及supplementary material
. ?# F2 r: x* Z. K% \# _# a9 k6 ncell stem cell 上有最新的一篇文章关于干细胞和5hmC的，链接是http://www.sciencedirect.com/science/article/pii/S1934590911003407，

游侠儿2012GX

我这里也有几篇，供大家参考
+ {7 c+ e# f1 s2 v2 c' |  TTET Genes: new players in DNA demethylation and important determinants for stemness, Experimental Hematology 2011;39:272–281
2 A5 R5 p: t, |' v) dTET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity,1 9 M AY 2 0 1 1 | VO L 4 7 3 | N AT U R E | 3 4 3
. g2 F- f; x0 DTet1 and Tet2 Regulate 5-Hydroxymethylcytosine
5 ]& n7 {( k0 G+ K3 ?, ?) JThe role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes

游侠儿2012GX

我在一篇文章里面看到Ayu17-449, a novel gene on mouse chromosome 3, was identified by the gene trapping technique previously reported by Tang et al. (2006). In NCBI database analysis, Ayu17-449 is also called TET-2 (tet oncogene family member 2). It belongs to a novel, well-conserved, protein family but with unclear biological function, the TET protein family, including three members (TET-1, TET-2 and TET-3). 不知道这tet2是不是Ayu17-449