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- 1030
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histone H3
) {; x' Q7 t9 c/ Hmethylation at lysine 9 is associated with heterochromatin and
) L0 Z4 s$ ^2 Lgene silencing, while histone H3 at lysine 4 or 27 is associated8 G( t8 O' E$ e3 j3 F Y! f& a- m
with transcriptional activation.
; m% r, Y0 I2 m* h% Z6 k1 y( g. _% @6 N: _
Each lysine residue may be0 Z8 b! R9 f5 p* A& d- x
methylated in the form of mono-, di-, or tri-methylation, adding
8 \" {3 q- `1 _5 ]5 a% w% kenormous complexity. Deciphering histone tail modifications1 @. j" O: b4 }8 Z* t
and defining a potential “histone code” controlling gene expression0 R1 ^$ a+ G: ~. W( f& F
represents an emerging field of epigenetic research 。% i0 F2 e. t8 ~# R: t& b1 D4 `
Whether the potential histone code is modifiable by environmental
* @% R% |7 w. @/ R- b# z; Sexposures, similar toDNAmethylation patterns, remains
: w% `- E( u% R. m' x$ ?( xto be determined.
: _+ v# P. ~% \% B+ T, y% R2 z可以的话请把汉语写下来,谢谢。里面有些术语我都不知道翻成什么。 |
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