PDF电子书《Therapeutic Monoclonal Antibodies: From Bench to Clinic》

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Zhiqiang An, "Therapeutic Monoclonal Antibodies: From Bench to Clinic"  $ T+ @3 |0 {  I% g, k, v5 M; r
Wiley | 2009 | ISBN: 0470117915 | 905 pages | PDF | 11,4 MB   
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0 _# C0 o* P9 T9 U8 Y70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies.
' ?% C3 D- ?4 ?0 v2 w' ^2 ~2 n4 a. qFirst book to address the discovery and development of antibody therapeutics in their entirety.8 {* E8 W4 n5 i+ b8 K& z" L
Most chapters contain experimental data to illustrate the principles described in them.8 s: j; j. y( N, O) x2 \
Authors provide detailed methodologies that readers can take away with them and use in their own laboratories" D0 ^1 m  m: x/ j" j' J
2010-7-12 18:23:52 上传下载附件 (32.22 KB)
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/ D4 e) h: r: l6 P( D4 [. BTHERAPEUTIC MONOCLONAL ANTIBODIES    -141 b7 m* e" b6 N7 V
    CONTENTS    -12
* Z  j( e* n' P) R7 r4 s' R( N1 y    FOREWORD    -86 }% m! w( |  g( i0 e( Y
    PREFACE    -6- P: W6 n( c& ?( B+ l
    CONTRIBUTORS    -4
- ~# @$ Q8 A+ T% }4 h: W7 \( F    PART I ANTIBODY BASICS    1" r/ t1 J5 S: c" |1 Y. O: J2 M
        1. Therapeutic Monoclonal Antibodies: Past, Present, and Future    3
# H6 D' C: J8 {6 l6 x        2. Antibody Molecular Structure    51
7 a6 g+ s# {" D7 |. L        3. Glycosylation of Therapeutic IgGs    67
5 R* X1 }, _& m- q) g9 x7 \+ n7 S        4. Antibody Databases and Tools: The IMGT(? Experience    91( G& `& Y: e) o$ e, K8 g
    PART II ANTIBODY SOURCES    115
" w3 Y3 U7 u3 d* {% v! X        5. Human Antibodies from Transgenic Mice    117, ]* c# y1 K5 Q7 K7 N
        6. Rabbit Hybridoma    1519 x* b4 L5 P9 f
        7. Human Antibody Repertoire Libraries    169
- k& ~: m$ x3 C4 o    PART III IN VITRO DISPLAY TECHNOLOGY    189$ Z% D& l/ j/ {0 @' u  \
        8. Antibody Phage Display    191$ O8 ~0 G3 g* ]
        9. Yeast Surface Display    213% g. J4 D% t; e
        10. Ribosomal Display    2391 {4 R, I2 R+ k8 h3 \+ }# t
        11. Bacterial Display of Antibodies    255
. p  J6 r& o8 p: Y9 S% y; ~  v        12. Antibody Selection from Immunoglobulin Libraries Expressed in Mammalian Cells    283
4 F$ g- Y: O* P7 g. z# i    PART IV ANTIBODY ENGINEERING    309. Q0 s6 O8 v7 y5 _" X8 T; I
        13. Antibody Engineering: Humanization, Affinity Maturation, and Selection Techniques    311
& P/ Y: ]6 K' q, ~" [3 b        14. Modulation of Serum Protein Homeostasis and Transcytosis by the Neonatal Fc Receptor    3359 W4 F7 C/ i& v. m3 A. [  l" t% n* W
        15. Engineering the Antibody Fc Region for Optimal Effector Function    3496 [7 F; T, \! z& m3 H# q0 ^
    PART V PHYSIOLOGY AND IN VIVO BIOLOGY    371
! u2 ?1 K6 F; w' V" P; t- B& v6 n        16. Antibody-Complement Interaction    373- Y/ l3 T+ M" n
        17. Bacteria Immunoglobulin-Binding Proteins: Biology and Practical Applications    385
( E& s9 C: k8 |5 A4 o        18. Immunogenicity Screening Using in Silico Methods: Correlation between T-Cell Epitope Content and Clinical Immunogenicity of Monoclonal Antibodies    417
" i# U( ]6 P2 F& G        19. Monoclonal Antibody Pharmacokinetics and Pharmacodynamics    4391 u: M7 S, ?: B. x' ^
        20. Biodistribution and Imaging    461
7 A+ N: H6 Z( {4 [4 D" _        21. Antibodies and the Blood-Brain Barrier    483. Q/ R8 o- p4 _+ n
    PART VI ANTIBODY CHARACTERIZATION    503
2 `7 G- @: Z* e- D        22. Determination of Equilibrium Dissociation Constants    505
& E$ P( }3 n+ `( Y( T' }% f        23. Molecular and Functional Characterization of Monoclonal Antibodies    525# w- A+ R; S( s/ E/ @$ b8 r
        24. Characterization of Heterogeneity in Monoclonal Antibody Products    541$ ~" t: ]: P& f
    PART VII ANTIBODY EXPRESSION    555! T  u; A/ M! ~$ D( K$ e/ p4 K- p
        25. Antibody Expression in Mammalian Cells    557
! e( T" n& l+ }2 C+ Q        26. Production of Antibodies in Pichia pastoris    573/ i7 Y8 a. j! X: i# C$ M  ]4 j4 T
        27. Production of Antibody Fab' Fragments in E. coli    589/ j9 \6 `# z4 D- V
        28. Production of Human Therapeutic Monoclonal Antibodies in Chicken Eggs    623
1 X0 o6 H. p6 S9 v, j% m        29. Production of Antibodies in Plants    651% ~* s+ k; @# S" t
    PART VIII THERAPEUTIC ANTIBODIES    673
; [) Y3 u: m, j8 }$ c1 T0 m" P" _        30. The Formulation and Delivery of Monoclonal Antibodies    6759 z3 l& b: Z' O# ?3 ?
        31. Therapeutic Antibodies in Clinical Use and Leading Clinical Candidates    711
; J6 [" W) D* T, D& v4 l8 u        32. Follow-On Protein Products: What, Where, When, How?    763
6 Q4 a: h4 @6 n$ N+ g8 O3 {5 Q6 T        33. Monomeric Fc Fusion Molecules    779. m8 v2 B& l; _: x/ \- X
        34. Radioimmunotherapy: Current Status and Future Directions    797
  |3 m" ]' E: T" _        35. Antibody-Drug Conjugate Therapy    821' q4 i* z8 L/ G/ S* F
    ABBREVIATIONS    857
2 e8 e1 j. B# Q  Y& ^* M9 w7 c    INDEX    865
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