求关于小分子在iPSCs诱导过程中的作用有关文献

genedu

各位大虾，谁手里有关于替代OCT4，SOX2，Klf4，c-Myc这四个因子以及其他诱导因子的小分子的文献？小弟拜谢了
" ^) v9 z8 E* ^; x9 _如果有哪位神人实际操作过的，请告知小分子名称及其用量。
' F5 I  Q; P' ^: g5 ]$ n6 C, C再次拜谢

cellbuddies

可以参考丁盛的文章，给你一个文章列表
+ x( J+ R% m. i# {( T7 hGeneration of Rat and Human Induced Pluripotent Stem Cells by Combining Genetic Reprogramming and Chemical Inhibitors
' G: c0 Q' E, G5 k- N- [Small molecules that modulate embryonic stem cell fate and somatic cell reprogramming2 k4 p0 l) v. z( ?
A chemical platform for improved induction of human iPSCs-supplemental methods and data
% N; P) [$ L0 g+ H7 a" V) n还有University of Cambridge的Austin Smiths
1 ?- E" i4 _) ePromotion of Reprogramming to Ground State Pluripotency by Signal Inhibition

cellbuddies

full text

cellbuddies

MEK inhibitor PD0325901 (Sigma, 0.5 μM)# ?( g1 _0 I/ K' s& Q: d( W
ALK5 inhibitor A-83-01 (Tocris Bioscience, 0.5 μM)  K" v9 @% o; l3 p8 X( }+ Q1 L% P
GSK3β inhibitor CHIR99021 (BioVision, 3 μM)5 q& }: ^  o  g0 c* F4 G
挺贵的，大概5000大洋

genedu

回复 cellbuddies 的帖子9 `* n1 Y; ?) ^! j; x

& m+ A9 |& }, M, Q/ u) h真是太感谢了。临帖涕零，不知所言