求关于小分子在iPSCs诱导过程中的作用有关文献

genedu

各位大虾，谁手里有关于替代OCT4，SOX2，Klf4，c-Myc这四个因子以及其他诱导因子的小分子的文献？小弟拜谢了: r& T$ @  [1 Y) c$ ~
如果有哪位神人实际操作过的，请告知小分子名称及其用量。
0 E! D' i) k/ a8 S% g# Q% A再次拜谢

cellbuddies

可以参考丁盛的文章，给你一个文章列表, _+ `+ Z" |; b/ T$ Q7 a' F  T. w
Generation of Rat and Human Induced Pluripotent Stem Cells by Combining Genetic Reprogramming and Chemical Inhibitors
: @. F4 _' A2 {* y- d' q6 kSmall molecules that modulate embryonic stem cell fate and somatic cell reprogramming
' j4 _, c3 a. b6 l: T. LA chemical platform for improved induction of human iPSCs-supplemental methods and data! O, O8 w5 c, b7 {7 q
还有University of Cambridge的Austin Smiths
# ?+ W6 }" n! |8 LPromotion of Reprogramming to Ground State Pluripotency by Signal Inhibition

cellbuddies

full text

cellbuddies

MEK inhibitor PD0325901 (Sigma, 0.5 μM)% c# B( x9 z& h! j+ Q
ALK5 inhibitor A-83-01 (Tocris Bioscience, 0.5 μM)
9 c3 L) P) x, {2 ~3 q" r; ?, {2 p( ?GSK3β inhibitor CHIR99021 (BioVision, 3 μM)
% ^- R; N& Y; D0 S  w挺贵的，大概5000大洋

genedu

回复 cellbuddies 的帖子
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真是太感谢了。临帖涕零，不知所言