干细胞免疫表型鉴定问题，请教！

haiq1984

间充质干细胞在鉴定时要CD90\CD73\CD105高表达，那这三个必须都高表达呢？
% q! I) R: r  n: g各个表型分别指征了什么呢？指教啊

haiq1984

我是想问下具体的每个表型代表的又是什么呢/?

haiq1984

回复 透明微笑 的帖子# d/ b, e" c# D- H7 w% r

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haiq1984

To identify MSC,we propose that cells should express CD105 (known as endoglin and originally recognized by the MAb SH2),CD73 (known as ecto 5' nucleotidase and originally recognized by the MAb SH3 and SH4) and CD90 (also known as Thy-1).- J" Z2 s1 b; Z* c& _# ]

haiq1984

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CD-90 plays a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain Thy-1 is the designation for a major cell surface glycoprotein characteristic to T cells,. The Thy-1 glycoproteins are constituents of thymocytes and neurons and probably are involved in cell-cell interactions. Human Thy-1 homolog maps to chromosome 11 because that is where T3D is found, in the mouse T3D and Thy-1 map to chromosome 9 along with certain other loci that are on human 11q.8 n" ~+ |1 p6 c& L9 p7 |5 f
CD105 is expressed on the cell surface as a 180 kDa homodimeric transmembrane protein,It is a receptor for transforming growth factor (TGF) -ß1 and -ß3 and modulates TGF-ß signaling by interacting with TGF-ß receptors I and/or II.Immunohistochemistry studies have revealed that CD105 is strongly expressed in blood vessels of tumor tissues.
& U& s" H8 K' O9 V0 g+ n7 MCD73 is a cell surface enzyme of the purine catabolic pathway that catalyzes the breakdown of AMP to adenosine./ M: R5 @/ e! l+ {  X% U
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抛砖引玉，希望大家能在这三种表型在鉴定间充质的原因上面发表些高见！

haiq1984

回复 大少爷 的帖子; V1 v0 X1 u) c: \0 p) W

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