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In additional mating studies we have conducted (as yet unpublished)2 I$ a+ C) [: F0 z2 M
using wild-type and HSF1 gene knockout mice,we have put individual mice through a 40-day continuous
3 C2 _3 }/ b7 B9 ebreeding assay following heat shock. Results from these" L# P/ ^, g% i4 ^, F
experiments separate the histopathologic lesions in early" ?; C1 o9 P/ B; O2 G
and late spermatogenic stages (i.e., apoptotic spermatocytes),+ [% Z$ C4 \: j. q1 M7 G( q. ?
which are dependent on HSF1 and inducible HSP
, ~7 [& Z/ v* u' s2 K- Uexpression, from longer-term effects on reproductive performance t; w, _. ]6 N- b/ }
relating to spermatocyte-specific but stage-independent2 G% S) [1 u! ?
effects.9 F9 k& f% n+ |8 y) D E6 X
来自文章Effects of Hyperthermia on Spermatogenesis, Apoptosis, Gene Expression,; {8 w! Y8 c3 H! S2 J3 ?, z
and Fertility in Adult Male Mice。/ n4 N# u+ s0 A% ]) J3 u: i5 ^
236页删划线部分$ S6 Y1 E9 s. v. B! X
; b* {. D, l' ?3 U; u {谢谢哦。 |
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