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In additional mating studies we have conducted (as yet unpublished)
; w; r ]4 q7 g4 ]. a! m% Pusing wild-type and HSF1 gene knockout mice,we have put individual mice through a 40-day continuous, X& E" {& }8 z+ C6 k: \' a
breeding assay following heat shock. Results from these4 J1 f- Z" X& b+ V7 l
experiments separate the histopathologic lesions in early
. a( m, R! e& xand late spermatogenic stages (i.e., apoptotic spermatocytes),3 Y3 M) u4 d7 I. Z c; L- W+ b
which are dependent on HSF1 and inducible HSP$ B1 G- Z5 @7 A' a
expression, from longer-term effects on reproductive performance* o) h. l+ E1 ?- ~: c
relating to spermatocyte-specific but stage-independent! |& [/ v$ X9 h* F! o& A
effects.
, U9 N* p% x8 t* O9 U6 W0 q' y来自文章Effects of Hyperthermia on Spermatogenesis, Apoptosis, Gene Expression,1 }5 ?6 `6 ?' L( J
and Fertility in Adult Male Mice。' J w& b+ v+ e3 p5 D/ Z
236页删划线部分- n0 S) s& m% n1 }
' b% K1 X2 [) s9 y1 J9 K8 f8 [
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