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In additional mating studies we have conducted (as yet unpublished)6 }' `& D. I! P* w3 V
using wild-type and HSF1 gene knockout mice,we have put individual mice through a 40-day continuous! Q4 a! a. [" W4 y9 [# R
breeding assay following heat shock. Results from these
. S8 L! R) A, T9 d: y- e& uexperiments separate the histopathologic lesions in early
" ]% f$ W% R; @) u1 dand late spermatogenic stages (i.e., apoptotic spermatocytes),
* v! \2 Z3 n/ ewhich are dependent on HSF1 and inducible HSP
! B. s$ s9 c0 Oexpression, from longer-term effects on reproductive performance
, b. `! k' q4 k- B, n7 a$ q( m6 q( }relating to spermatocyte-specific but stage-independent
& O1 n' Y( R. N4 O; s, j8 B! yeffects.2 R7 h' T2 V: t4 a g3 t& ^
来自文章Effects of Hyperthermia on Spermatogenesis, Apoptosis, Gene Expression,
0 G2 O. A8 H3 X/ ]1 F+ s" Hand Fertility in Adult Male Mice。5 E8 I) M p- H- A
236页删划线部分1 o! s1 v" C$ e. f
8 u, v. T; H3 ^; m5 b, [
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