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In additional mating studies we have conducted (as yet unpublished)/ J" g5 p( A5 C1 C
using wild-type and HSF1 gene knockout mice,we have put individual mice through a 40-day continuous
8 A9 S0 g3 |8 N' m( m. Obreeding assay following heat shock. Results from these
$ d, w0 y8 A5 uexperiments separate the histopathologic lesions in early
: B5 ^+ Q/ \5 |and late spermatogenic stages (i.e., apoptotic spermatocytes),
/ A4 H/ n& G; k6 j" q9 swhich are dependent on HSF1 and inducible HSP
8 M! I I/ O; e$ N" f, Q% W$ J yexpression, from longer-term effects on reproductive performance
/ D; A9 h4 g" w' `" k% v, ]$ drelating to spermatocyte-specific but stage-independent; K1 A& U' h: L; n# r; B
effects.
* a& a ^4 Y, K3 z" U来自文章Effects of Hyperthermia on Spermatogenesis, Apoptosis, Gene Expression,
1 R1 |/ Q) d- m# Oand Fertility in Adult Male Mice。
5 e. E, I. c1 D! H236页删划线部分7 G$ `* S5 |2 `5 i2 G# }$ {
1 H p& v/ ~9 J' k$ g! T谢谢哦。 |
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