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In additional mating studies we have conducted (as yet unpublished)4 X( V, n$ q) N' h
using wild-type and HSF1 gene knockout mice,we have put individual mice through a 40-day continuous
9 N n5 G% |6 a( Q0 w- G) Ibreeding assay following heat shock. Results from these# Q' l2 `* `+ o& k% H
experiments separate the histopathologic lesions in early
9 |- d7 `3 o# |) H+ m/ _1 x. @and late spermatogenic stages (i.e., apoptotic spermatocytes), s/ n0 s' e$ s( z$ ]5 u4 c
which are dependent on HSF1 and inducible HSP& o" |' ]9 s! p$ a' P" i/ k
expression, from longer-term effects on reproductive performance
1 C" \ U5 C5 _, s, O9 H+ s1 [) z4 Drelating to spermatocyte-specific but stage-independent2 @7 Q! j& W: X# Y9 S
effects.
3 U* h6 `3 I, b6 `2 C来自文章Effects of Hyperthermia on Spermatogenesis, Apoptosis, Gene Expression,
2 M* [, ^3 ~$ ~+ Dand Fertility in Adult Male Mice。
4 D' o2 l0 o- }236页删划线部分' H# R' F4 j, @ p7 o
% \1 t/ L7 }* O1 P/ R, ~谢谢哦。 |
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