|
- 积分
- 71
- 威望
- 71
- 包包
- 6
|
本帖最后由 细胞海洋 于 2012-3-26 13:34 编辑
4 M: C8 m" C! m0 E7 S" {8 b! i8 |- I5 F% [) i6 @- k4 q6 N
Cellular DNA is subjected to continual attack, both by reactive species inside5 i+ u$ u! s2 G: z& g, S: [
cells and by environmental agents. Toxic and mutagenic consequences are
& _+ \3 t, a9 b @minimized by distinct pathways of repair, and 130 known human DNA repair
* Q( H0 N8 k* R' U- N' qgenes are described here. Notable features presently include four enzymes that. {+ e8 T8 A4 r% J
can remove uracil from DNA, seven recombination genes related to RAD51, and
( ]: w9 f! b# a0 [8 b* zmany recently discovered DNA polymerases that bypass damage, but only one. y$ B, X1 f4 p7 s5 @/ Y/ H/ Y
system to remove the main DNA lesions induced by ultraviolet light. More
- [; j% i+ b' g khuman DNA repair genes will be found by comparison with model organisms* f. t" O) l7 q! U5 }! y
and as common folds in three-dimensional protein structures are determined.
4 {: m3 k% Q' ?" HModulation of DNA repair should lead to clinical applications including im-
3 s/ N* |# g# G- Z" D1 |/ R0 Pprovement of radiotherapy and treatment with anticancer drugs and an ad-
3 O1 Z- a* h+ Z! ?' v# yvanced understanding of the cellular aging process.
4 m4 ~' Z8 f3 t; ]& |- g1 q
, y! u% b1 |; j0 I3 Q& V* J[hide][/hide] |
附件: 你需要登录才可以下载或查看附件。没有帐号？注册
-
总评分: 包包 + 5
查看全部评分
|
发表于 2012-3-26 11:00
