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本帖最后由 细胞海洋 于 2012-3-26 13:34 编辑
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0 ^' i" l0 t/ ]$ u* VCellular DNA is subjected to continual attack, both by reactive species inside! \- L' v8 b8 [$ [4 _: O/ s
cells and by environmental agents. Toxic and mutagenic consequences are
3 S- s" y% R5 Uminimized by distinct pathways of repair, and 130 known human DNA repair
, N% Z9 e1 v; B3 v, H8 e# X* [genes are described here. Notable features presently include four enzymes that- ?9 n7 k6 y; d( u- h- H
can remove uracil from DNA, seven recombination genes related to RAD51, and
& B; y9 ]* W' U* zmany recently discovered DNA polymerases that bypass damage, but only one
5 b; S, c. E u+ x" B; y1 ?system to remove the main DNA lesions induced by ultraviolet light. More
; U! N- I+ {( H( _/ khuman DNA repair genes will be found by comparison with model organisms
* ]/ ]" r0 `1 qand as common folds in three-dimensional protein structures are determined.( w2 t) v# @1 W" f" F9 L
Modulation of DNA repair should lead to clinical applications including im-, T9 r9 z @- s2 j
provement of radiotherapy and treatment with anticancer drugs and an ad-
* d5 t0 x- F: |vanced understanding of the cellular aging process.( |+ ~2 G/ `* ]3 j" N
" b7 G/ Z) A/ L* ` A[hide][/hide] |
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发表于 2012-3-26 11:00
