|
- 积分
- 71
- 威望
- 71
- 包包
- 6
|
本帖最后由 细胞海洋 于 2012-3-26 13:34 编辑 * }9 C$ X8 E2 b0 x! k
( z3 ?: {$ I! S- e2 iCellular DNA is subjected to continual attack, both by reactive species inside: g* n' D- C/ R
cells and by environmental agents. Toxic and mutagenic consequences are- _- M0 l5 ~) S% s7 v5 p! i: X
minimized by distinct pathways of repair, and 130 known human DNA repair
2 u {. E5 K. I; C3 m5 r% g0 sgenes are described here. Notable features presently include four enzymes that5 X& C& t$ a9 G$ B+ R+ e
can remove uracil from DNA, seven recombination genes related to RAD51, and% R* Q8 F' m5 p G9 D
many recently discovered DNA polymerases that bypass damage, but only one
2 K, n1 e/ x3 k4 R. Fsystem to remove the main DNA lesions induced by ultraviolet light. More! C4 k& _$ Q$ ^0 h
human DNA repair genes will be found by comparison with model organisms8 v+ B7 g# g" n* c
and as common folds in three-dimensional protein structures are determined.
! |- ~: [' U4 J! z O- }7 D, X* X+ x4 qModulation of DNA repair should lead to clinical applications including im-
( @$ n+ t# p' p5 ?6 sprovement of radiotherapy and treatment with anticancer drugs and an ad-
: i# W! J; G* u9 |% i$ R9 D, s ?4 }$ Wvanced understanding of the cellular aging process.
( l8 `2 `0 x9 i/ n" v
) d# p! x! O/ z) P[hide][/hide] |
附件: 你需要登录才可以下载或查看附件。没有帐号？注册
-
总评分: 包包 + 5
查看全部评分
|
发表于 2012-3-26 11:00
