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本帖最后由 细胞海洋 于 2012-3-26 13:34 编辑
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, y: b$ @ Z6 f6 m6 W% GCellular DNA is subjected to continual attack, both by reactive species inside
) F* d6 S0 i, x0 t0 ]2 Scells and by environmental agents. Toxic and mutagenic consequences are/ ?% z0 n' L( P( O4 O/ x
minimized by distinct pathways of repair, and 130 known human DNA repair# Q) O+ m% P( ~& P$ m) t
genes are described here. Notable features presently include four enzymes that
' N3 ^9 H' T3 G. _" ~can remove uracil from DNA, seven recombination genes related to RAD51, and, m; R: N: n* s- Z% h% K9 H3 @& P7 u
many recently discovered DNA polymerases that bypass damage, but only one* w" H& f2 z5 k. a
system to remove the main DNA lesions induced by ultraviolet light. More' ]9 X* a: s$ W2 |6 k
human DNA repair genes will be found by comparison with model organisms
4 }/ I" D3 T# O: f- P. |and as common folds in three-dimensional protein structures are determined.- }! Q1 p- Z* p# ^1 ^
Modulation of DNA repair should lead to clinical applications including im-
* S1 [. Z' L$ O8 dprovement of radiotherapy and treatment with anticancer drugs and an ad-
" h+ e4 Y9 v6 j2 A8 `* \5 u9 p, lvanced understanding of the cellular aging process.& a3 k9 d- T* A7 D
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发表于 2012-3-26 11:00
