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本帖最后由 细胞海洋 于 2012-3-26 13:34 编辑 $ ~( M2 z8 T5 i; n
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Cellular DNA is subjected to continual attack, both by reactive species inside
8 Q I' A4 C7 Lcells and by environmental agents. Toxic and mutagenic consequences are
, V- F w4 U" \6 Bminimized by distinct pathways of repair, and 130 known human DNA repair- b& G# @: H/ F9 h
genes are described here. Notable features presently include four enzymes that
" x+ I6 f0 F( h0 `6 }can remove uracil from DNA, seven recombination genes related to RAD51, and
: u! }% R6 V- S0 M3 ^- ?! k, {many recently discovered DNA polymerases that bypass damage, but only one' P: e5 @7 ?' e; j+ x+ Q' A5 ]
system to remove the main DNA lesions induced by ultraviolet light. More
5 g9 d: p& E7 A O9 N0 Chuman DNA repair genes will be found by comparison with model organisms
. L2 z e" u7 n5 uand as common folds in three-dimensional protein structures are determined./ ]" I0 V3 f5 d$ T& ^
Modulation of DNA repair should lead to clinical applications including im-8 z- |# x6 P' C
provement of radiotherapy and treatment with anticancer drugs and an ad-
% Z+ _' h% D: M2 Xvanced understanding of the cellular aging process.% Y. Y$ [/ N5 z, b! z/ p
5 b2 d3 H' b ^; W+ d* I, r[hide][/hide] |
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发表于 2012-3-26 11:00
