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本帖最后由 细胞海洋 于 2012-4-13 22:22 编辑
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Volume 149, Issue 2
/ H& k9 u% |5 x4 `On the cover: Congenital scoliosis is a human birth defect that results in 2 G6 ?; X$ D5 ^: F9 K$ c
spinal curvature caused by vertebral defects. In this issue, Sparrow et al. (pp.
6 }! b E2 R+ @) x295–306) demonstrate that such defects in humans and mice can be caused by & y1 s, e# l" @8 O b1 p6 k
haploinsufficiency of Notch signaling pathway genes. In mice, this genetic risk
3 C& a! g N# \ }$ Ofactor combined with an environmental condition (short-term hypoxia) # X- p Y" [! d" q6 X7 m/ n
significantly increases the penetrance and severity of vertebral defects. The
9 Z* c/ Y) b1 U# l. S6 scover photograph shows severe vertebral and rib defects of an embryonic mouse
6 ?. N% R/ _3 q; P: C" Bcontaining a null allele of a Notch signaling pathway target gene and exposed to
, d% ]1 E" q+ E) n" Wa brief period of hypoxia during gestation.
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发表于 2012-4-13 13:28
发表于 2012-4-15 15:10
