《细胞》[Cell]12年4月27日出版pdf全文

nero1981

7 a  K: \. O  U) e2 L/ d' XVolume 149, Issue 39 Q3 r3 ]2 i9 t( ?# A
On the cover: The combined activity of neurons in the brain generates
$ T' _& ~" d3 O1 Q. [! H/ woscillatory rhythms, or “brain waves,” that can be detected by 3 J& ]: B1 R3 z
electroencephalographic recordings. Verret et al. (pp.708–721) found that these ! L- I3 ^7 B* T0 @$ j4 I. E0 H' `2 Q" g
brain waves, which are represented on the cover by an undulating pattern, are 8 F& d. J+ o5 j6 P  b) K/ I
altered in mouse model of Alzheimer's disease (AD), and the changes are linked 7 s* v$ |: M! L6 J
to reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring 7 e# j5 Y/ A6 k3 ~1 t' g# E
Nav1.1 levels specifically in inhibitory interneurons improves oscillatory . n/ J: e" ^) Z
rhythms and memory in AD mice, offering a new therapeutic approach for
& _3 d* s6 I; a9 y1 v" s2 Spotentially treating cognitive disorders. The image was created by Arantxa
8 ^, \! G* a* O9 N3 b2 sEsteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop
' ^: b) w7 u& X* R( `/ E0 C(electronic recreation).
# p, M4 J+ m+ \# v9 g- X# W[hide][/hide]