《细胞》[Cell]12年4月27日出版pdf全文

nero1981

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Volume 149, Issue 3
$ A# k0 P0 I- FOn the cover: The combined activity of neurons in the brain generates
/ r* M  x7 n: K. l$ k3 Joscillatory rhythms, or “brain waves,” that can be detected by * j7 |$ H! A7 ]) i4 w: ^" C% W# v# ~
electroencephalographic recordings. Verret et al. (pp.708–721) found that these 9 Z( H/ o! D" `+ H, |6 N
brain waves, which are represented on the cover by an undulating pattern, are . A+ _; M+ m. E, S& O% I; V, n
altered in mouse model of Alzheimer's disease (AD), and the changes are linked + V6 [! u/ A$ H* t$ u  W
to reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring 7 T6 I9 }8 |) ^* a/ F
Nav1.1 levels specifically in inhibitory interneurons improves oscillatory
9 u. S- _: D8 E7 P& @rhythms and memory in AD mice, offering a new therapeutic approach for
- r! F5 P  C4 W# Tpotentially treating cognitive disorders. The image was created by Arantxa
+ |+ U5 F* \! T; X8 {, Y% p* R) x- h6 OEsteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop   @+ M' P4 `$ q8 u" z# M
(electronic recreation).
( K6 w8 d. b4 U' u" @[hide][/hide]

menghy

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cytobiology

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