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9 R% l: V( {9 vVolume 149, Issue 3
+ F2 q6 F. n' L: q. ^On the cover: The combined activity of neurons in the brain generates " Y) i T; E( _; Z& C& }1 b
oscillatory rhythms, or “brain waves,” that can be detected by $ h% j& U' b& \- H4 L1 j3 O
electroencephalographic recordings. Verret et al. (pp.708–721) found that these
0 |- [0 ~& F- Nbrain waves, which are represented on the cover by an undulating pattern, are
) R6 t! X. ?3 q& @. Ualtered in mouse model of Alzheimer's disease (AD), and the changes are linked
5 E2 G8 v* U& P9 i' sto reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring
* \# O& L: D) gNav1.1 levels specifically in inhibitory interneurons improves oscillatory
0 f5 }4 z u. n9 zrhythms and memory in AD mice, offering a new therapeutic approach for
# H7 F& T" z" G' Apotentially treating cognitive disorders. The image was created by Arantxa ; s; l# ~" Q4 W
Esteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop 5 f7 K# x1 }" q E9 ~
(electronic recreation).! h3 {5 \( s5 j/ O
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