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2012年11月 Nature Medicine& l! Z- h1 t5 j+ j* R
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In this issue, Andrew Weng and his colleagues uncover a new * L `2 X3 `: f/ A, Y% q: l4 h+ X% B
mechanism by which oncogenes regulate leukemia stem cells. Notch-driven 6 |6 P% ^$ M) n/ C( x2 T m9 w
inactivation of PKCθ attenuates the accumulation of . ?0 w1 ^- E7 j+ V( M6 Q3 a
reactive oxygen species to lower oxidative stress in the stem cell population of " T8 m2 U9 }7 q' R
T cell acute lymphoblastic leukemia (ALL), contributing to tumorigenesis. The
" u+ f, g$ {5 n& gimage shows an electron micrograph of erythrocytes and lymphocytes from a ' w7 q4 @8 V8 H# m/ D
patient with ALL. Photo by Steve Gschmeissner/Science Photo Library. . X R" H% i$ h: v1 W* \
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6 Z. u4 ~' ~6 g$ L `& t[hide][/hide] |
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发表于 2012-11-10 12:55
发表于 2012-11-12 16:35
