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2012年11月 Nature Medicine O2 o! |- E0 x
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In this issue, Andrew Weng and his colleagues uncover a new * w) K- g. t% c2 `' \7 R. X
mechanism by which oncogenes regulate leukemia stem cells. Notch-driven
( q+ |+ i" k% Z+ f# ?inactivation of PKCθ attenuates the accumulation of
, m# W! N) V$ @7 b$ c6 W, A$ qreactive oxygen species to lower oxidative stress in the stem cell population of % D( ? U( }# [# x6 L& v& ?/ Z
T cell acute lymphoblastic leukemia (ALL), contributing to tumorigenesis. The . ^/ W" v2 _7 R8 r$ T
image shows an electron micrograph of erythrocytes and lymphocytes from a 6 P" _, |) C {$ l5 G9 }3 c! P6 S: [' q
patient with ALL. Photo by Steve Gschmeissner/Science Photo Library. 9 ]; u3 b0 C: \' m
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