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2012年11月 Nature Medicine8 A5 M% |; \6 j* j) U4 ~9 A
: C& }, U! G% ?* tIn this issue, Andrew Weng and his colleagues uncover a new ; v8 d6 @- q' b! f' {! [2 [+ e
mechanism by which oncogenes regulate leukemia stem cells. Notch-driven 5 D5 l: w% I: w: o+ N
inactivation of PKCθ attenuates the accumulation of ! B& e# V3 e( u/ b3 ~" j
reactive oxygen species to lower oxidative stress in the stem cell population of # e, G1 ~, y6 G1 Z
T cell acute lymphoblastic leukemia (ALL), contributing to tumorigenesis. The
- ^7 ?7 l1 n+ R1 Z+ p, T0 x% ]image shows an electron micrograph of erythrocytes and lymphocytes from a ; y7 j* D2 }5 F
patient with ALL. Photo by Steve Gschmeissner/Science Photo Library. 0 }: |3 @8 E9 I8 [* t4 J: o
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发表于 2012-11-10 12:55
发表于 2012-11-12 16:35
