PDF电子书：Cancer Epigenetics - Methods and Protocols （2012）

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ISSN 1064-3745 e-ISSN 1940-6029" I4 d9 S- U7 t/ j4 c+ G: f
ISBN 978-1-61779-611-1 e-ISBN 978-1-61779-612-8* }$ i; e: \+ Z, ]$ ]
DOI 10.1007/978-1-61779-612-8
( ]$ Q* c$ q! h1 z/ ESpringer New York Dordrecht Heidelberg London3 l( |' p# J& V. g- p* g1 H0 m9 {
Library of Congress Control Number: 2012931559% k# [  }# u1 j4 W6 }* Y+ d8 v! L
© Springer Science+Business Media, LLC 20127 U( \  R: F5 x+ M

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Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 m& @" C5 Y4 _) [
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Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . + h& x0 ~; P5 w/ {3 m, X, ^; ]; B& o
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PART I   EARLY EPIGENETIC EVENTS IN CANCER
6 y! `/ b) H' I5 J' W4 V( |3 P0 J$ ^) }1   Epigenetic Markers of Early Tumor Development . . . . . . . . . . . . . . . . . . . . . .      
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Ramona G. Dumitrescu. g6 ]1 @/ r8 n8 o/ d) L% x6 i4 f6 s
2   Epigenetics of Solid Cancer Stem Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . .
5 \7 t: y8 o% J$ A7 `0 k1 V" m( T. .       15
6 R# V! _" E# [( q: H& pAlok Mishra and Mukesh Verma/ o. S  l: W. U5 I
PART II    CANCER SPECIFIC TYPE EPIGENETIC CHANGES) O! j: F4 d0 Y, J' }: h
3   DNA Methylation and Histone Modifications in Breast Cancer . . . . . . . . . . . .       35+ a9 b( y$ b6 C  x- O
Ramona G. Dumitrescu
( J; Z; r# r. N: h: h4  DNA Methylation Changes in Prostate Cancer . . . . . . . . . . . . . . . . . . . . . . . .      & ?3 K+ V, I, Z  f& K4 k, S
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Wolfgang Goering, Michael Kloth, and Wolfgang A. Schulz: n9 F" f7 v( p
5   DNA Methylation in Promoter Region as Biomarkers
3 \8 s- {. x9 I5 ]; ?$ m3 |in Prostate Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Mihi Yang and Jong Y. Park
. g( T3 {0 U! W1 K& N6   Epigenetics of Bladder Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Wun-Jae Kim and Yong-June Kim
# a. u/ f/ ]% [' b( g; D! a7  Epigenetics in Myeloid Malignancies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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" j+ g/ L1 Z8 b+ ?" JStefan Deneberg6 {3 h- D! B# _! [0 x1 T  Y5 n" }
8   The Epigenetics of Brain Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ) v, q5 ^+ b+ x: E4 F6 [
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Adrian M. Dubuc, Stephen Mack, Alexander Unterberger, Paul A. Northcott, and Michael D. Taylor
2 U# E& Q+ v; Z. y% V2 s9  DNA Methylation Changes in Cervical Cancers . . . . . . . . . . . . . . . . . . . . . . .    155% W0 u! T- q! S8 t0 ]1 k
Qiang Lu, Dehua Ma, and Shuping Zhao" S* h! k& u, ~* }; T# f
10   Epigenetics of Colon Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Sharad Khare and Mukesh Verma8 J5 t+ ^0 u' l4 X9 ^0 y
11  Promoter Methylation in Head and Neck Tumorigenesis. . . . . . . . . . . . . . . . .    187
. z! o; \/ Z& OJosena K. Stephen, Kang Mei Chen, Shaleta Havard, Glynis Harris, and Maria J. Worsham
5 p0 y' Q1 x9 f' o, B12   Epigenome and DNA Methylation in Oral
; \7 t8 l; }- G% @7 L) F" VSquamous Cell Carcinoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . , H& G& A7 _" Z) K- r+ }1 }/ f, M
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Mario Pérez-Sayáns García and Abel García-García2 c1 U' _/ H; L' r
Mario Pérez-Sayáns García and Abel García-García3 O$ f0 h9 O3 I/ X: ~5 g( v

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viii           Contents
1 U9 F5 I+ W) f8 Z" N7 E13   Clinical Implications of Epigenetic Alterations in Human
: D- {5 J' H* F3 A% O. k6 e/ PThoracic Malignancies: Epigenetic Alterations in Lung Cancer . . . . . . . . . . . .     221+ \% @- S. A5 N: v
Keiko Shinjo and Yutaka Kondo
; ~# o7 a' D  b# z14   The Role of MicroRNAs in the Management of Liver Cancer . . . . . . . . . . . . .     241
! j7 P% J) G8 K- V+ s* z* {& _Krishna K. Banaudha and Mukesh Verma" r4 f5 W" s) n3 ]9 X7 l
15   Epigenetics in Ovarian Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . " I  }, s+ B+ U
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L.M.S. Seeber and P.J. van Diest
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PART III   METHODS AND TECHNOLOGIES USED FOR EPIGENETIC CHANGES’ DETECTION
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16   DNA Methylation in Pancreatic Cancer: Protocols+ M7 l+ v# s, M* m" A6 b( l. p7 c
for the Isolation of DNA and Bisulfite Modification . . . . . . . . . . . . . . . . . . . .     273
% U/ F1 l1 K: o6 K% Y% A, Q  F4 PKatja Biewusch, Marie Heyne, Robert Grützmann, and Christian Pilarsky
7 ]. r! u9 k7 x% `: p2 `/ E17   Detection and Analysis of DNA Methylation by Pyrosequencing . . . . . . . . . . .     281
8 Y6 W, H) [7 i  |3 m0 x/ K0 ^. R7 |Hilary A.A. Colyer, Richard N. Armstrong, Daniel J. Sharpe, and Ken I. Mills2 a: S( O* q$ q1 c9 J
18   Screening for miRNA Expression Changes Using Quantitative
' U, q# N! d  s7 ~8 g$ W) pPCR (Q-PCR) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Richard N. Armstrong, Hilary A.A. Colyer, and Ken I. Mills1 J3 W0 N8 x) X" w" @
19   Genome-Wide Methylation Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
* b% J/ l% y4 \* D( t.     303
! N; T8 p) N+ g' B% HAlexander Unterberger, Adrian M. Dubuc, and Michael D. Taylor
+ {: [2 B0 y4 G) \! |8 m20  Microarray for Epigenetic Changes: Gene Expression Arrays . . . . . . . . . . . . . .   319! Q7 Q' X2 c- E. q  l  z6 k$ }0 r$ k' C
Hilary A.A. Colyer, Richard N. Armstrong, and Ken I. Mills
# l# F( k: C/ R7 D! Q21  Detecting DNA Methylation Using the Methylated CpG
8 Q1 P; K( ]( P& h( uIsland Amplification and Microarray Technique. . . . . . . . . . . . . . . . . . . . . . . .     3 J! H! M! s5 K
329
4 h3 B! l+ B* |! W, L6 b7 iHilary A.A. Colyer, Margaret Dellett, and Ken I. Mills
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) e& K* `" Y- {+ b/ h' u% N' j1 K9 SPART IV  FACTORS THAT INFLUENCE THE EPIGENETIC CHANGES IN CANCER" E/ t7 p- y! H* F# c
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22   Nutrigenomics: Implications for Breast and Colon Cancer Prevention . . . . . . .     343
. Y- g; g$ j% d, g% j9 R) EGabriela Riscuta and Ramona G. Dumitrescu
- ^, M% ^+ E. S# z' z' o6 d4 G23   Dietary and Lifestyle Factors of DNA Methylation . . . . . . . . . . . . . . . . . . . . .     
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Unhee Lim and Min-Ae Song6 A' P6 X/ g, |3 B$ _
24   Diet, Epigenetics, and Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 a! k: X3 K3 M( G9 W, L8 `
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L. Joseph Su& p4 s1 K# C' d+ z& G+ I% F
25   Role of Epigenetics in Cancer Health Disparities . . . . . . . . . . . . . . . . . . . . . . . 7 b# C; L. z8 o' X! ?
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Sulma I. Mohammed, Sanya Springfield, and Rina Das# O" x8 h- n% A9 f- E- l4 j
26   Multifactorial Etiology of Gastric Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . - A8 G- ]4 y. U, h& [
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5 X1 t8 y. p. I& J4 jJovanny Zabaleta
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Contents             ix/ Z4 y2 V  M* q% T$ g( ]

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. G9 D/ Z" k7 W" R( F; L- E$ ?: R8 \PART V    EPIGENETIC EPIDEMIOLOGY
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; b- k* J4 c9 n" l8 M27  Epigenetic Epidemiology for Cancer Risk: Harnessing Germline% o# _- O  z0 m; }, D6 B
Epigenetic Variation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 b2 q: f# K" d% y7 [, M" W3 ?
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Kevin Brennan and James M. Flanagan
$ |0 i4 y2 a. s' q" _7 ]+ h28   Epigenetic Biomarkers in Cancer Epidemiology. . . . . . . . . . . . . . . . . . . . . . . .    4 L( f. X7 W0 H! b
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Mukesh Verma
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