PDF电子书：Cancer Epigenetics - Methods and Protocols （2012）

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( A$ t+ V6 W4 E  F* h0 _" j* N[hide][/hide]1 g" b8 l2 I, I$ M: z6 I

/ r0 A# {) u( E( xISSN 1064-3745 e-ISSN 1940-60293 v8 K+ N$ M; s2 P4 }
ISBN 978-1-61779-611-1 e-ISBN 978-1-61779-612-8
; ?$ o2 J& ~0 E6 M; s& `! XDOI 10.1007/978-1-61779-612-8
( Y# N: [- j2 \) ]Springer New York Dordrecht Heidelberg London
" p4 v! h6 w9 u4 h& VLibrary of Congress Control Number: 2012931559! ]  [8 u. r4 E/ D. O8 O
© Springer Science+Business Media, LLC 20122 d) m! p9 c4 Y  f" P, Q

2 ~# A6 B3 B# o2 n1 E3 o7 X8 GContents
& N0 g3 e* s9 p" p5 j; @Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 c5 ]* `0 {( o6 P
. . . . . . . . . . . .         v
6 }& O/ N+ b" U/ t- Z" ~' QContributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
/ |7 _3 i4 F3 }4 s# Y/ g. . . . . . . . . .        xi
& W+ n0 m( f) A. {7 O) }PART I   EARLY EPIGENETIC EVENTS IN CANCER
6 r% ^2 z# ?. e4 O2 y; z6 N% [1   Epigenetic Markers of Early Tumor Development . . . . . . . . . . . . . . . . . . . . . .      
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Ramona G. Dumitrescu' O0 Z# P* X6 L0 I
2   Epigenetics of Solid Cancer Stem Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . ; z1 _( w  E5 U4 [$ C
. .       15  I1 q: C7 }  S
Alok Mishra and Mukesh Verma! h' Q% d5 F+ X$ T( I
PART II    CANCER SPECIFIC TYPE EPIGENETIC CHANGES( U/ n. b+ k/ c
3   DNA Methylation and Histone Modifications in Breast Cancer . . . . . . . . . . . .       354 j* P; q/ Y2 g  A
Ramona G. Dumitrescu0 }) w: X. c/ B+ K- e( c2 _
4  DNA Methylation Changes in Prostate Cancer . . . . . . . . . . . . . . . . . . . . . . . .      
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Wolfgang Goering, Michael Kloth, and Wolfgang A. Schulz
1 r; b6 Z* P& x  V* P5   DNA Methylation in Promoter Region as Biomarkers
1 H8 o( Q0 n! J0 d5 O* ^in Prostate Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . * h/ p( e* P6 m5 Z+ @/ c3 O
. . . . .      67
0 X. h0 B, V# r8 h* PMihi Yang and Jong Y. Park
% [$ @2 A4 b9 V5 r/ X; p* A6   Epigenetics of Bladder Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . + {9 z6 l/ O, w  E- N
. . . .     111! X' J2 _% Z: `- m' H( Z
Wun-Jae Kim and Yong-June Kim; L! U1 [( h- Q( j- M& {
7  Epigenetics in Myeloid Malignancies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
; Z: r& {. c" H3 r. o. .    1194 q$ o8 |- i9 y
Stefan Deneberg
$ N/ W  f$ p- l  G; j9 ?! h8   The Epigenetics of Brain Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
8 N4 m, d6 a$ ~  d! f/ M. .     139  g1 t+ t% ~- z$ ~
Adrian M. Dubuc, Stephen Mack, Alexander Unterberger, Paul A. Northcott, and Michael D. Taylor$ n: n& n" d# q0 x4 H' }8 J
9  DNA Methylation Changes in Cervical Cancers . . . . . . . . . . . . . . . . . . . . . . .    155  {3 C6 @" ^: c, h/ W, S
Qiang Lu, Dehua Ma, and Shuping Zhao% f, y9 Z9 M7 R7 Z2 E
10   Epigenetics of Colon Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 t" d. q' E! {' s; G1 ~( O
. . . . .     1775 v4 I, @- h; M5 R9 s) E$ D' }# [5 p
Sharad Khare and Mukesh Verma* Z; l$ K' d5 F5 [: H
11  Promoter Methylation in Head and Neck Tumorigenesis. . . . . . . . . . . . . . . . .    187. L2 ?9 U& n4 G7 `& d7 H
Josena K. Stephen, Kang Mei Chen, Shaleta Havard, Glynis Harris, and Maria J. Worsham3 g: ]1 @' ?- C& m+ S7 Y0 u$ A
12   Epigenome and DNA Methylation in Oral
7 ?8 o  V; ~  Q3 P% `' l3 e+ A/ QSquamous Cell Carcinoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   V/ }, d) u3 B, G9 t. L2 G
.    207
0 u3 b+ Q- F  |: U$ f+ hMario Pérez-Sayáns García and Abel García-García
) A+ a' p) A, z0 w0 G8 TMario Pérez-Sayáns García and Abel García-García* C: C! h4 S7 Y1 b1 ~5 K" N

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0 \; [! I8 |9 [: W6 M8 S$ Mviii           Contents) g) z1 V( `7 _& `4 N
13   Clinical Implications of Epigenetic Alterations in Human
7 p' M: Y/ s  _) R# d5 |5 H7 b- sThoracic Malignancies: Epigenetic Alterations in Lung Cancer . . . . . . . . . . . .     221- k" I9 v/ t* w% c9 k* C
Keiko Shinjo and Yutaka Kondo
+ p5 A4 ]6 ^/ |" j4 B4 V14   The Role of MicroRNAs in the Management of Liver Cancer . . . . . . . . . . . . .     241
) v0 o/ O7 b, _) MKrishna K. Banaudha and Mukesh Verma
9 m- h& |) r7 R7 _6 t% w3 ]2 c6 w# l15   Epigenetics in Ovarian Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1 B/ E" ?% o8 C/ U. . . .     253
6 Z3 f* y' d) [( l2 }) oL.M.S. Seeber and P.J. van Diest
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PART III   METHODS AND TECHNOLOGIES USED FOR EPIGENETIC CHANGES’ DETECTION2 t! |5 R* K: T0 }
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16   DNA Methylation in Pancreatic Cancer: Protocols0 L( |0 g0 X9 w: q( J* m' L
for the Isolation of DNA and Bisulfite Modification . . . . . . . . . . . . . . . . . . . .     273
' N) A) f7 E. [" @Katja Biewusch, Marie Heyne, Robert Grützmann, and Christian Pilarsky
1 E) q% G) E8 z5 }17   Detection and Analysis of DNA Methylation by Pyrosequencing . . . . . . . . . . .     281
3 \, ?# j+ m1 _  G, b. Y% G$ ZHilary A.A. Colyer, Richard N. Armstrong, Daniel J. Sharpe, and Ken I. Mills
+ u$ ]+ X0 B7 f" o18   Screening for miRNA Expression Changes Using Quantitative
, P0 z5 B$ ]7 y/ b; L1 CPCR (Q-PCR) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
$ }. O: v3 G: O5 ~. . . .    293
. n( H7 Q9 a, O( h( @& T7 qRichard N. Armstrong, Hilary A.A. Colyer, and Ken I. Mills! T6 U; D. a, b0 z
19   Genome-Wide Methylation Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ; W' C+ P) Y+ V6 c- O: @1 g( B
.     3037 q1 V; d- e7 K1 X7 v
Alexander Unterberger, Adrian M. Dubuc, and Michael D. Taylor
+ e  K5 v6 o- r5 p# p. r% \3 K' m" e20  Microarray for Epigenetic Changes: Gene Expression Arrays . . . . . . . . . . . . . .   3191 s% }, h/ a4 g+ W6 W) W
Hilary A.A. Colyer, Richard N. Armstrong, and Ken I. Mills
, X0 }1 u; l. N5 C! f# g21  Detecting DNA Methylation Using the Methylated CpG
; f1 ~) F$ Y5 m3 D3 R, X) I) Q# pIsland Amplification and Microarray Technique. . . . . . . . . . . . . . . . . . . . . . . .     
- k7 h9 d9 X* G( h329/ ~; H3 s/ N$ T, X0 v9 e2 j& N6 A
Hilary A.A. Colyer, Margaret Dellett, and Ken I. Mills/ y# g( z" w( @% h6 ?
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PART IV  FACTORS THAT INFLUENCE THE EPIGENETIC CHANGES IN CANCER
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1 w6 ~  v7 S1 _  d22   Nutrigenomics: Implications for Breast and Colon Cancer Prevention . . . . . . .     343$ A0 a* y% I' F$ k
Gabriela Riscuta and Ramona G. Dumitrescu
3 a6 _3 |4 z0 `' }23   Dietary and Lifestyle Factors of DNA Methylation . . . . . . . . . . . . . . . . . . . . .     6 i0 z" h, Q" K1 I) F4 L
359
1 e( U, X2 t8 \$ @Unhee Lim and Min-Ae Song
' x9 B1 ]8 ]& @0 O24   Diet, Epigenetics, and Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . I" u8 N+ ~% A9 b8 {0 }
. . . . .     377
9 G( l2 x+ W5 k6 J0 }/ _L. Joseph Su
* ^4 O- V/ `$ r2 }; X1 m) H) T$ C25   Role of Epigenetics in Cancer Health Disparities . . . . . . . . . . . . . . . . . . . . . . .
7 I( _8 v9 q, Y    395
* m& y3 X2 p* @$ V# ISulma I. Mohammed, Sanya Springfield, and Rina Das
9 E+ O* h$ D  w- ^26   Multifactorial Etiology of Gastric Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . : @2 k, P1 U6 {( v( w9 b& ?/ b
. .     411
+ C, _8 F6 _( ^2 p) X4 YJovanny Zabaleta5 c- [3 N. |: i, p6 z# o/ e  w

) h% j9 Y8 K" \" g# N( ^Contents             ix
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$ j' s$ M9 q2 P, }) e1 `4 Q# |PART V    EPIGENETIC EPIDEMIOLOGY& m& D7 ~1 B5 _% w+ G

0 \4 M/ j% F; P# P27  Epigenetic Epidemiology for Cancer Risk: Harnessing Germline
: H) O* N0 T  g/ x8 R9 P; D* N9 DEpigenetic Variation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
2 p, T9 W: K' L: N- w# l. . . . .    439
6 d: F7 t! I# e5 b1 v/ ?Kevin Brennan and James M. Flanagan; S4 f4 h/ l1 A% R' G  I2 g
28   Epigenetic Biomarkers in Cancer Epidemiology. . . . . . . . . . . . . . . . . . . . . . . .    9 v' U4 }7 Z/ D! M6 w& q
467
) C. f# k+ U/ ?# c3 Z* O  DMukesh Verma! I+ D' q/ M- c' m
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . % a8 J  ?3 w8 i; |
. . . . . . . . . . . .     481
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