PDF电子书：Cancer Epigenetics - Methods and Protocols （2012）

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0 P+ j4 i% h4 dISSN 1064-3745 e-ISSN 1940-6029
3 k3 L- F$ ?8 _8 z3 v% q; QISBN 978-1-61779-611-1 e-ISBN 978-1-61779-612-8
- F! j/ _  l9 ?* g1 V) w6 yDOI 10.1007/978-1-61779-612-8
$ `+ D1 q5 b. _7 c# WSpringer New York Dordrecht Heidelberg London
6 _1 Y  f, L" sLibrary of Congress Control Number: 2012931559
9 l5 `. m% |! L1 H© Springer Science+Business Media, LLC 2012
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Contents
  H- O* @$ m' r$ ZPreface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 o# M' V% v$ N9 V$ V
. . . . . . . . . . . .         v$ I' Q6 |" J4 F. u; k& a6 w
Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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PART I   EARLY EPIGENETIC EVENTS IN CANCER9 N: F% |. C) k
1   Epigenetic Markers of Early Tumor Development . . . . . . . . . . . . . . . . . . . . . .       : F' P" A4 j( `; U* O1 G- v) R
  3
. n5 ~: W9 t( `* NRamona G. Dumitrescu9 U; p# H( ^" e
2   Epigenetics of Solid Cancer Stem Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . ( L- U$ b! _. ], |
. .       15
3 `) c* i3 w8 a. n$ }Alok Mishra and Mukesh Verma
. I5 _. A; P6 ^) M3 s; X$ PPART II    CANCER SPECIFIC TYPE EPIGENETIC CHANGES$ f1 V: @- Q( Z/ z  ^5 R/ x
3   DNA Methylation and Histone Modifications in Breast Cancer . . . . . . . . . . . .       35' I0 z6 }5 [. d$ Q6 M  C, H
Ramona G. Dumitrescu5 V& n) J/ _0 @4 t5 K8 M+ Z
4  DNA Methylation Changes in Prostate Cancer . . . . . . . . . . . . . . . . . . . . . . . .      
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Wolfgang Goering, Michael Kloth, and Wolfgang A. Schulz
6 k' D* t* W: n8 I  s; h" ?5   DNA Methylation in Promoter Region as Biomarkers
8 O4 v- h( D" y' C( S5 Nin Prostate Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
4 H  Z' X" z6 C2 b. . . . .      67
5 ~3 A; }! z1 P! X' XMihi Yang and Jong Y. Park1 k8 f" s! f& \6 t$ u" w  f7 {
6   Epigenetics of Bladder Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ( i$ u! D0 v# r5 ]: _
. . . .     111( P4 Q5 _' i6 a& u1 ]3 d
Wun-Jae Kim and Yong-June Kim4 B4 R, D1 p" V3 d) }- ^
7  Epigenetics in Myeloid Malignancies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 I( t$ D, i2 b5 W8 Y
. .    119
7 F  s, T9 h  R0 l2 t' {& [9 uStefan Deneberg
9 V# j' t1 M) t  Z! c1 v8   The Epigenetics of Brain Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 K% i8 A, j; P3 U
. .     139
# V5 _5 |7 @3 u5 s% X6 eAdrian M. Dubuc, Stephen Mack, Alexander Unterberger, Paul A. Northcott, and Michael D. Taylor/ ?2 E, L$ b: G6 d% P$ Z4 P
9  DNA Methylation Changes in Cervical Cancers . . . . . . . . . . . . . . . . . . . . . . .    1557 A8 `! d+ V& w/ z# E& p
Qiang Lu, Dehua Ma, and Shuping Zhao, Q7 F$ {. Z  b+ Y/ L4 ]1 f
10   Epigenetics of Colon Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . }) i' R8 X# l3 w/ R" d* J/ S5 u
. . . . .     177
  }$ w- v3 M' y( L! X) RSharad Khare and Mukesh Verma" j7 a. Q: x+ ]- |
11  Promoter Methylation in Head and Neck Tumorigenesis. . . . . . . . . . . . . . . . .    187
. y" e' \8 P# k) p: n" @' E- PJosena K. Stephen, Kang Mei Chen, Shaleta Havard, Glynis Harris, and Maria J. Worsham
' N7 M& b7 v- e: I/ B  b# v12   Epigenome and DNA Methylation in Oral4 W- X# |" \; I
Squamous Cell Carcinoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . " \; D( \- g# X; L- f
.    207
0 H6 Q7 Z7 a$ b+ qMario Pérez-Sayáns García and Abel García-García
6 C7 y1 `+ H0 ?0 M; K. a$ xMario Pérez-Sayáns García and Abel García-García5 b" [' B* M3 A  g1 J! Y# K

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% z6 y9 Y: `3 Y' R. Q) z& qviii           Contents
3 ?# B2 G3 b6 Q0 S1 P9 \13   Clinical Implications of Epigenetic Alterations in Human
8 Y% d; o& f& e( ^: Z8 |' a/ `3 \  }Thoracic Malignancies: Epigenetic Alterations in Lung Cancer . . . . . . . . . . . .     2219 b! S, @: a8 r$ C1 B  a" ~/ n
Keiko Shinjo and Yutaka Kondo
" I# ?; f; }! t14   The Role of MicroRNAs in the Management of Liver Cancer . . . . . . . . . . . . .     241# n0 B" M9 J' C
Krishna K. Banaudha and Mukesh Verma
% z! A/ c7 G* z- l0 g15   Epigenetics in Ovarian Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
: J# b! q. o' ~. e2 |" H. . . .     253
5 e7 X. D) H* \L.M.S. Seeber and P.J. van Diest1 t5 T& ^( W1 {3 t3 K9 P/ e
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PART III   METHODS AND TECHNOLOGIES USED FOR EPIGENETIC CHANGES’ DETECTION
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16   DNA Methylation in Pancreatic Cancer: Protocols
8 F' A: j! o9 l( r% yfor the Isolation of DNA and Bisulfite Modification . . . . . . . . . . . . . . . . . . . .     273
( ]: H4 C; X8 Z) MKatja Biewusch, Marie Heyne, Robert Grützmann, and Christian Pilarsky2 h+ p5 m$ M, X
17   Detection and Analysis of DNA Methylation by Pyrosequencing . . . . . . . . . . .     281/ s/ n2 |, Q: ?( t$ @. D
Hilary A.A. Colyer, Richard N. Armstrong, Daniel J. Sharpe, and Ken I. Mills7 [" e% p* _( }
18   Screening for miRNA Expression Changes Using Quantitative
/ N* \+ z# R6 S/ UPCR (Q-PCR) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . & i; m7 I+ s9 o( o
. . . .    293
1 w9 a- R. P; a- \4 dRichard N. Armstrong, Hilary A.A. Colyer, and Ken I. Mills
* {+ A1 p+ b2 t" U1 Z" U& S19   Genome-Wide Methylation Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Y. Z3 I" m6 Z1 R' i' s
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Alexander Unterberger, Adrian M. Dubuc, and Michael D. Taylor
* {9 G8 ^; q( M+ T) @20  Microarray for Epigenetic Changes: Gene Expression Arrays . . . . . . . . . . . . . .   319
  Y) ~% z- j$ j+ S! ]5 IHilary A.A. Colyer, Richard N. Armstrong, and Ken I. Mills
  j; H* J# ~$ n- i* ~  G21  Detecting DNA Methylation Using the Methylated CpG' B! v; R# q0 o. o" t- I. \( s
Island Amplification and Microarray Technique. . . . . . . . . . . . . . . . . . . . . . . .     8 P& Y8 h. f( r$ J% y- V1 k
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Hilary A.A. Colyer, Margaret Dellett, and Ken I. Mills
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PART IV  FACTORS THAT INFLUENCE THE EPIGENETIC CHANGES IN CANCER
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! ^/ k9 c. C% ?) B22   Nutrigenomics: Implications for Breast and Colon Cancer Prevention . . . . . . .     343
1 C( _7 p5 T- w. ^9 L3 Q+ N. SGabriela Riscuta and Ramona G. Dumitrescu
5 e* P) B8 F: w* c/ H* g1 D2 j23   Dietary and Lifestyle Factors of DNA Methylation . . . . . . . . . . . . . . . . . . . . .       u) c' h7 b/ D$ O
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Unhee Lim and Min-Ae Song' K! v, k" R- C% J
24   Diet, Epigenetics, and Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $ b& ^7 g& K, ^
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L. Joseph Su
7 n- x- O2 L/ n4 d0 [/ s8 x. h6 O25   Role of Epigenetics in Cancer Health Disparities . . . . . . . . . . . . . . . . . . . . . . .
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Sulma I. Mohammed, Sanya Springfield, and Rina Das
( B& K  b" X+ k1 C/ b26   Multifactorial Etiology of Gastric Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . , t5 t1 O9 q8 B/ b5 h
. .     411: ]2 _  R- q3 P! c# \; i
Jovanny Zabaleta
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Contents             ix3 e/ ?+ \0 b6 Q; O% s9 X4 i2 L# E

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5 e, A- K, U! \' I9 h7 LPART V    EPIGENETIC EPIDEMIOLOGY
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! t1 V8 r. p3 d/ o8 N27  Epigenetic Epidemiology for Cancer Risk: Harnessing Germline
& F* R" Q: w( l7 S" |$ VEpigenetic Variation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
4 r# s9 F- g  H9 K. . . . .    439
# ^! d6 l1 d& eKevin Brennan and James M. Flanagan
" b) h; t7 A2 y  x  e28   Epigenetic Biomarkers in Cancer Epidemiology. . . . . . . . . . . . . . . . . . . . . . . .   
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Mukesh Verma( `3 A; D* K6 v8 I: X0 A' l
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
# C* x# \3 H+ o+ @) X. . . . . . . . . . . .     481
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