PDF电子书：Cancer Epigenetics - Methods and Protocols （2012）

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- L4 p( A# p9 s& w- R/ q+ B% TISSN 1064-3745 e-ISSN 1940-6029
+ W0 P7 R! w# x2 D  e- IISBN 978-1-61779-611-1 e-ISBN 978-1-61779-612-80 C) l3 }$ R% `9 v* R  G
DOI 10.1007/978-1-61779-612-84 d6 c7 U% l, j+ }
Springer New York Dordrecht Heidelberg London% {: J5 s7 w( x' W
Library of Congress Control Number: 2012931559
: s! _5 t' z" J) A: ^/ \© Springer Science+Business Media, LLC 2012
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Contents
/ ]. t# ?6 K: l* U& h& h* ^/ u8 v4 XPreface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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% d/ w5 n7 D3 M# H4 PContributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
$ E/ ?& f# Y4 N4 g0 C& e$ z. . . . . . . . . .        xi
! B9 z# Z- S1 ]PART I   EARLY EPIGENETIC EVENTS IN CANCER! l# W& E( U! g* g6 D5 ^: d
1   Epigenetic Markers of Early Tumor Development . . . . . . . . . . . . . . . . . . . . . .       " r5 H2 j* H2 A- t$ k5 W$ p* I; [# W
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Ramona G. Dumitrescu; D/ K! ^, h( _8 x6 [
2   Epigenetics of Solid Cancer Stem Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . * U% k$ d) ~) t- P- O8 Q
. .       15# ~. i( j$ W& X3 ^
Alok Mishra and Mukesh Verma5 I- G+ r0 R; I6 Y9 b
PART II    CANCER SPECIFIC TYPE EPIGENETIC CHANGES0 ?" G* G# K- |
3   DNA Methylation and Histone Modifications in Breast Cancer . . . . . . . . . . . .       35# |, a1 E+ B+ L1 `1 n
Ramona G. Dumitrescu. p) [5 |1 @- |! c' ]- P
4  DNA Methylation Changes in Prostate Cancer . . . . . . . . . . . . . . . . . . . . . . . .      
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) t' i9 u, z( DWolfgang Goering, Michael Kloth, and Wolfgang A. Schulz
" M0 ^- E1 a: |/ w& `5   DNA Methylation in Promoter Region as Biomarkers
" ~0 e0 t; `  E( {in Prostate Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
/ s: n4 e8 W* T$ l  p5 O8 m. . . . .      67
7 a) ?( b3 Y3 c. e1 d9 _+ XMihi Yang and Jong Y. Park
# a; |. v3 E" W7 P  j6   Epigenetics of Bladder Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Wun-Jae Kim and Yong-June Kim. [1 y/ v. M  f' k6 V; N, x
7  Epigenetics in Myeloid Malignancies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Q2 }  ~7 w; [/ m
. .    119
: R4 ]2 x" o. K& R4 a6 ?3 _Stefan Deneberg
# L* Z% B2 J9 @0 a; C7 D! w8   The Epigenetics of Brain Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Adrian M. Dubuc, Stephen Mack, Alexander Unterberger, Paul A. Northcott, and Michael D. Taylor
9 i) k) e4 m! }3 g8 c$ k9  DNA Methylation Changes in Cervical Cancers . . . . . . . . . . . . . . . . . . . . . . .    155
9 M! x( E8 m5 s8 u7 `7 A3 t0 Z7 a- bQiang Lu, Dehua Ma, and Shuping Zhao
5 ?4 ]" z6 u' a- W9 P! S10   Epigenetics of Colon Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
9 z, V8 C) p( {! |/ z. . . . .     177
0 k% \, b* S3 u4 Q" w1 f& ^Sharad Khare and Mukesh Verma6 W0 f7 V8 g  h( w) v
11  Promoter Methylation in Head and Neck Tumorigenesis. . . . . . . . . . . . . . . . .    187: H7 C8 ?6 i$ v2 \' c: I: P- S: j- G
Josena K. Stephen, Kang Mei Chen, Shaleta Havard, Glynis Harris, and Maria J. Worsham
! G$ a, S8 b: L5 ]1 _( D4 x1 J- s. u12   Epigenome and DNA Methylation in Oral# h( ]5 X' [% m6 w8 h/ }
Squamous Cell Carcinoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Mario Pérez-Sayáns García and Abel García-García
' g# A" A% C5 {9 J* `Mario Pérez-Sayáns García and Abel García-García! n) N; w! T; b2 f

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viii           Contents% D; r% A; R0 \: @, k7 f
13   Clinical Implications of Epigenetic Alterations in Human
, Q) I- C* A- j  ^, ?Thoracic Malignancies: Epigenetic Alterations in Lung Cancer . . . . . . . . . . . .     221
) C) Q. g6 Y% y! KKeiko Shinjo and Yutaka Kondo2 C+ |# K2 R' L! s" A# W. Z
14   The Role of MicroRNAs in the Management of Liver Cancer . . . . . . . . . . . . .     241
, d# A' h) A7 }( E( T) l) TKrishna K. Banaudha and Mukesh Verma% I, E7 f5 l3 M/ T& p$ A5 [
15   Epigenetics in Ovarian Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . , o3 \+ B& M9 c* i0 v; [$ Q
. . . .     253
8 _4 }# Z- q' D% S- @L.M.S. Seeber and P.J. van Diest* `2 ]) W- x# Y  E6 M4 D; x0 p
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PART III   METHODS AND TECHNOLOGIES USED FOR EPIGENETIC CHANGES’ DETECTION6 C, v8 y) M& s3 d  \) |" p% V
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16   DNA Methylation in Pancreatic Cancer: Protocols; R: P, U$ O! A
for the Isolation of DNA and Bisulfite Modification . . . . . . . . . . . . . . . . . . . .     273
* q  ]% p' v6 BKatja Biewusch, Marie Heyne, Robert Grützmann, and Christian Pilarsky. w. c, z7 m9 Y# |- W6 g' t
17   Detection and Analysis of DNA Methylation by Pyrosequencing . . . . . . . . . . .     281/ n6 d, @. ~: `( S, x# R9 S% s
Hilary A.A. Colyer, Richard N. Armstrong, Daniel J. Sharpe, and Ken I. Mills+ M/ J; t5 {+ M; K8 ?9 ]" d
18   Screening for miRNA Expression Changes Using Quantitative1 e# \& e8 R, C4 s5 L
PCR (Q-PCR) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $ h- |0 [) O( _
. . . .    293. W( |4 v6 \7 c( Y) N
Richard N. Armstrong, Hilary A.A. Colyer, and Ken I. Mills* Y1 b4 h) j. k" s. r' V
19   Genome-Wide Methylation Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
* P" W1 A6 b* B" R.     303
& p# @# `9 P% ?! v6 b7 DAlexander Unterberger, Adrian M. Dubuc, and Michael D. Taylor
& h9 D: B5 V6 q$ o20  Microarray for Epigenetic Changes: Gene Expression Arrays . . . . . . . . . . . . . .   319
) ]  {: j9 ~6 T( iHilary A.A. Colyer, Richard N. Armstrong, and Ken I. Mills
+ g7 E. y1 h2 m5 L6 _9 `21  Detecting DNA Methylation Using the Methylated CpG
, G6 [3 T4 k; k, F; P/ {Island Amplification and Microarray Technique. . . . . . . . . . . . . . . . . . . . . . . .     8 m1 m. D- P* |- e- b5 m
329
* E1 B6 q% S$ R+ h" r+ l# THilary A.A. Colyer, Margaret Dellett, and Ken I. Mills# p! L' y& @& X" v/ h
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PART IV  FACTORS THAT INFLUENCE THE EPIGENETIC CHANGES IN CANCER/ d) v0 r# u9 u+ d: m" h6 h# e% @1 q

# B! J2 T* q8 E+ j" h# i22   Nutrigenomics: Implications for Breast and Colon Cancer Prevention . . . . . . .     343
7 }" V7 v5 B& ~1 J% H6 PGabriela Riscuta and Ramona G. Dumitrescu  ~" u( _# h8 Y6 ?! g
23   Dietary and Lifestyle Factors of DNA Methylation . . . . . . . . . . . . . . . . . . . . .     - o( D4 T& q- f# _/ k& i' D
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Unhee Lim and Min-Ae Song0 F( V1 h0 e$ j4 u
24   Diet, Epigenetics, and Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . + p4 t* n, {6 D( ?' c4 F
. . . . .     3774 b% i# j0 q; M1 r* k; [. B+ B% T
L. Joseph Su
# X, k4 f* h4 {+ |# l* A25   Role of Epigenetics in Cancer Health Disparities . . . . . . . . . . . . . . . . . . . . . . .
+ E+ w* H* p3 \2 G6 {8 W4 ^3 F    395
, B5 N' |3 }4 N" j' S" [Sulma I. Mohammed, Sanya Springfield, and Rina Das
( e* z* {' Z. p7 o2 Z26   Multifactorial Etiology of Gastric Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . 9 ^" V% @( l. m3 ?3 ^, Q: Q( J8 i
. .     4116 M( C5 a& u# x/ ^1 f& ^1 V1 B% U
Jovanny Zabaleta
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Contents             ix
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PART V    EPIGENETIC EPIDEMIOLOGY3 {- T7 o9 C* f* n! Q: e  V0 g
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27  Epigenetic Epidemiology for Cancer Risk: Harnessing Germline
( q9 Y3 Y) ?2 `9 U8 ~' K# M* |Epigenetic Variation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . + S! E' l8 z- T5 l& j1 ~
. . . . .    4394 ?( s- ~, E, j3 y
Kevin Brennan and James M. Flanagan) z: {2 g. E, X5 k! j( B6 Q
28   Epigenetic Biomarkers in Cancer Epidemiology. . . . . . . . . . . . . . . . . . . . . . . .   
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Mukesh Verma5 P1 Z5 ]- A) X6 x4 D
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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