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本帖最后由 细胞海洋 于 2013-3-29 18:59 编辑
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/ H3 r) y v" B9 \Volume 153, Issue 1, G/ R- a6 @. w, U6 f7 J2 {, K! _
On the cover: The kind of food an organism consumes has a broad reaching
' `# j+ F3 K. K+ E4 k4 H3 M- u8 yimpact on its development, behavior, and lifespan. In this issue, two
/ r! d3 [; F: u# t2 F( i+ [papers, MacNeil et al. (pp. 240–252) and Watson et al. (pp. 253–266), explore
d3 e; O% b! Pthe effects of diet on these life-history traits in the nematode C. - E1 z/ v1 D% X" D( p+ [) B$ H2 G
elegans. Combining nutrigenomics and network analyses, they find that
/ r# }! V! {5 y% f! Hdifferent diets affect traits via distinct mechanisms. The response to diet is x# d$ c0 x5 k7 p
coupled to metabolic changes, and disruptions of some of these specific ( g$ X# v7 O' ~ j" J/ k
metabolic pathways correspond to inborn errors of metabolism in humans. The 7 R( f: f( h0 L( P) s( z% t
cover features a “native-art-inspired abstraction” of a worm eating a bacterial
$ M4 H8 U( v2 r8 A( gdiet and illustrates the interconnectedness between diet, nuclear gene
, R7 S/ @+ ]( Y* r# D( W: B Uregulatory networks, mitochondrial networks, and their effects on life-history ) O) }8 V7 Y7 T2 E2 L
traits such as development and brood size. Cover art by Lesley T. MacNeil.4 ^: V. p T/ ~
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