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本帖最后由 细胞海洋 于 2013-3-29 18:59 编辑
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) X$ W# o1 I6 E6 s" RVolume 153, Issue 1
# y, w: P% M0 K! ~7 k3 X0 F/ kOn the cover: The kind of food an organism consumes has a broad reaching
, |1 i: L/ V, ?+ b n+ b4 E& yimpact on its development, behavior, and lifespan. In this issue, two
4 G2 D/ u" b- g; o" y' Hpapers, MacNeil et al. (pp. 240–252) and Watson et al. (pp. 253–266), explore 8 A& k/ n m! c: T
the effects of diet on these life-history traits in the nematode C.
1 }; H4 A, p1 t* E- t2 Aelegans. Combining nutrigenomics and network analyses, they find that 0 e: P, y6 D2 C p6 v
different diets affect traits via distinct mechanisms. The response to diet is : g% _% r8 {6 j
coupled to metabolic changes, and disruptions of some of these specific
; r- f+ B7 G) `9 h; l" Wmetabolic pathways correspond to inborn errors of metabolism in humans. The
" d. K0 i4 b' ~cover features a “native-art-inspired abstraction” of a worm eating a bacterial
" ?/ f4 n) K% n: u+ H' Z. ?% ^diet and illustrates the interconnectedness between diet, nuclear gene
9 ^" y. J. H! l {! i8 Kregulatory networks, mitochondrial networks, and their effects on life-history
$ a% y/ O: C& w; n4 c3 D" Btraits such as development and brood size. Cover art by Lesley T. MacNeil.1 `/ |0 X' \% ^1 G9 E4 D: I/ N! ], c
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