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Volume 38, Issue 5
/ u' R/ v- @" b. m l+ Q- mOn the cover: Regulation of metabolic pathways in the immune system provides
( w3 ?1 ~. d! a0 k/ u6 P6 s0 t# z8 Ia mechanism to actively control cellular function, growth, proliferation, and 3 I& R! Z L( n1 |# b7 n
survival. However, the contribution of microRNAs to the regulation of cellular
) ?; F' o2 R8 C H+ gmetabolism in the immune system is unclear. In this issue of Immunity, 9 `' M, O- L+ D" b* v
Henao-Mejia et al. (984–997) show that the miR-181 family is a critical ; f: G# G4 T! s8 B
determinant of cellular metabolism, and therefore it is essential to support the . ]' M" w7 H. V! w/ L/ c" M9 _8 E/ a% b
high biosynthetic demands of lymphocyte development. In particular, regulation
8 @* ?- t/ Q1 F3 o8 F+ z+ hof cellular metabolic pathways by miR-181 is absolutely required for early
- k) b: u8 N7 @) E8 jnatural killer T cell development. The cover cartoon depicts a lymphocyte that - l& L% i; ^" ]/ i9 X
necessitates the presence of miR-181 (represented as an electrical plug) to , v# G1 \( H8 M# \ A
maintain a robust metabolism. Thus, in the absence of miR-181 (unplugged
/ a5 g U( J }, r# m% Istatus), the lymphocyte lacks the energy to efficiently carry out normal " M, q9 `8 }0 l% x9 e) ]4 k
functions. Image created by Gustavo Zapata.
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发表于 2013-5-24 20:52
发表于 2013-5-24 21:18
