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Volume 38, Issue 5
7 y: t8 Q* U6 X! r) OOn the cover: Regulation of metabolic pathways in the immune system provides
* N6 @1 Q. l2 I! Da mechanism to actively control cellular function, growth, proliferation, and / X# s0 ^( z, i2 z- Q3 a& G
survival. However, the contribution of microRNAs to the regulation of cellular
; _: }# h) Q5 F3 Q" jmetabolism in the immune system is unclear. In this issue of Immunity, ! a+ D2 v2 i& r6 t d
Henao-Mejia et al. (984–997) show that the miR-181 family is a critical ) G* N s8 ^, k
determinant of cellular metabolism, and therefore it is essential to support the " S& P& w2 Y+ Y" f5 [& N
high biosynthetic demands of lymphocyte development. In particular, regulation , W; d0 x0 T! Z, }4 C0 W3 [2 ]+ G
of cellular metabolic pathways by miR-181 is absolutely required for early
' M7 O5 C l6 D0 Z& Z- gnatural killer T cell development. The cover cartoon depicts a lymphocyte that
0 n9 J3 A5 u; k ~necessitates the presence of miR-181 (represented as an electrical plug) to
e! y8 V5 W1 ^4 k! ~maintain a robust metabolism. Thus, in the absence of miR-181 (unplugged
" u) {6 c( S& ^3 k& [0 M( t% n& t8 o% dstatus), the lymphocyte lacks the energy to efficiently carry out normal 3 E. Y( ^) J# b3 u2 ~% R0 ^
functions. Image created by Gustavo Zapata.
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发表于 2013-5-24 20:52
发表于 2013-5-24 21:18
