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 5 F: J' z3 W, C! U% `6 @- X
Volume 38, Issue 5
* ?, d/ @- V9 f6 W# M; POn the cover: Regulation of metabolic pathways in the immune system provides
1 T1 X, e m4 R/ B. z* aa mechanism to actively control cellular function, growth, proliferation, and
; }' y7 b. W9 ~0 psurvival. However, the contribution of microRNAs to the regulation of cellular
9 i1 q; z5 J M9 lmetabolism in the immune system is unclear. In this issue of Immunity,
8 C7 s8 T$ h0 [) h# C/ A% s9 [Henao-Mejia et al. (984–997) show that the miR-181 family is a critical
1 d: @8 e9 U2 K! z2 e, i; ?determinant of cellular metabolism, and therefore it is essential to support the F5 t3 c9 n) O7 K* z/ r3 i" [
high biosynthetic demands of lymphocyte development. In particular, regulation
% G% c: B0 l( u% v" qof cellular metabolic pathways by miR-181 is absolutely required for early + x. T( l8 ^8 A2 {+ m( J; c5 M# g
natural killer T cell development. The cover cartoon depicts a lymphocyte that , k% l n3 I7 G0 y, t+ F ]
necessitates the presence of miR-181 (represented as an electrical plug) to
6 X2 s r- m \4 B* hmaintain a robust metabolism. Thus, in the absence of miR-181 (unplugged 6 ?/ ^9 l+ @. x
status), the lymphocyte lacks the energy to efficiently carry out normal
0 N4 O6 V0 Y# S3 g0 y/ ufunctions. Image created by Gustavo Zapata.& Z0 h0 r& q( G0 ?
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发表于 2013-5-24 20:52
发表于 2013-5-24 21:18
