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 ) }4 ?1 P8 @' D6 b0 T% }2 A4 J
Volume 38, Issue 5
1 Z0 V% r1 p4 p- W# d7 X( G/ B! ?! GOn the cover: Regulation of metabolic pathways in the immune system provides ! L0 v* s; e$ _; g
a mechanism to actively control cellular function, growth, proliferation, and
7 _3 K5 e8 r- [% csurvival. However, the contribution of microRNAs to the regulation of cellular
: z7 h- [/ ?# F+ S. o7 K& g0 p2 o. D, ometabolism in the immune system is unclear. In this issue of Immunity, : ^" C* f6 \. N0 j, b
Henao-Mejia et al. (984–997) show that the miR-181 family is a critical 9 t; z* o' b3 ~0 S/ w, G! r3 a6 b
determinant of cellular metabolism, and therefore it is essential to support the
9 _: z# j! Z- ^8 U& `high biosynthetic demands of lymphocyte development. In particular, regulation
- M3 c" u' B) r3 s; Zof cellular metabolic pathways by miR-181 is absolutely required for early * r0 K/ w; d4 H: ]: u& c
natural killer T cell development. The cover cartoon depicts a lymphocyte that
, ?# C) R8 W- E: F2 B' Unecessitates the presence of miR-181 (represented as an electrical plug) to
( Q- b d5 u1 ^3 Fmaintain a robust metabolism. Thus, in the absence of miR-181 (unplugged : C0 n2 M* x: }6 s: B% x' J8 s
status), the lymphocyte lacks the energy to efficiently carry out normal
! p( w: M3 b5 j2 ^4 }+ m, f8 ~functions. Image created by Gustavo Zapata.
. t4 ]6 _/ ^) G5 b |
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发表于 2013-5-24 20:52
发表于 2013-5-24 21:18
