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Volume 38, Issue 5
3 f, j1 U% e# l2 D3 T L# y! \On the cover: Regulation of metabolic pathways in the immune system provides
6 A2 A( B: W3 l+ ?" La mechanism to actively control cellular function, growth, proliferation, and # X2 ` y2 x' e' I- U8 \- o
survival. However, the contribution of microRNAs to the regulation of cellular - P! v) q) O9 m+ t5 b H: c' f
metabolism in the immune system is unclear. In this issue of Immunity, , K4 A# l: M& j% l
Henao-Mejia et al. (984–997) show that the miR-181 family is a critical # ~0 L0 H" K1 m, {4 Q0 Z6 R: t- `
determinant of cellular metabolism, and therefore it is essential to support the 1 B( A; a" D5 ?5 m4 W' d; \8 N; |
high biosynthetic demands of lymphocyte development. In particular, regulation ! j$ A: Z& I& ^ N; I }8 I
of cellular metabolic pathways by miR-181 is absolutely required for early ( s; c3 ?. b* a* h
natural killer T cell development. The cover cartoon depicts a lymphocyte that 1 {- d' S1 @" Y ]3 G% f, ^
necessitates the presence of miR-181 (represented as an electrical plug) to ( l+ ~; k2 v6 j X
maintain a robust metabolism. Thus, in the absence of miR-181 (unplugged
% f& j& v# ] F7 [5 H H4 ~status), the lymphocyte lacks the energy to efficiently carry out normal ! |1 p7 z; ]% f2 w( q
functions. Image created by Gustavo Zapata.
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发表于 2013-5-24 20:52
发表于 2013-5-24 21:18
