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Toxoplasma gondii infects the mouse gut and induces . t! `7 @4 u/ P4 x$ N. b' x: r: }$ n; U
an inflammatory response mediated by neutrophils that damages the intestinal
) T# D2 H J6 m8 stissue and leads to proliferation and translocation of commensal bacteria. In
6 E" h; P4 A6 K: r3 z2 P+ zthis issue, Grainger et al. report that commensal bacteria help temper ! M1 b% H% @+ f2 N2 w
the inflammation caused by T. gondii by stimulating inflammatory
0 p* l, x& i2 Q% ]. c& smonocytes to release prostaglandin E2, which dampens neutrophil activity. The
4 W+ D5 u- J) \/ p3 kcover depicts commensal bacteria in blue and intestinal villi in red in mice
" N- l2 t+ m( o1 s/ K4 b3 ^infected with T. gondii. Image credit: Lily Y. Koo and Michael J. Molloy.
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发表于 2013-6-8 20:34
发表于 2013-6-10 15:54
