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; M7 R- s) S/ \. Q; xToxoplasma gondii infects the mouse gut and induces 2 U0 J8 p7 o" O& I
an inflammatory response mediated by neutrophils that damages the intestinal 8 V# s i2 D' A) C0 F( E1 c
tissue and leads to proliferation and translocation of commensal bacteria. In
# N& l5 Z2 ]7 H1 q; I k+ e" f6 rthis issue, Grainger et al. report that commensal bacteria help temper
6 N5 Q- I# k9 c6 [6 b$ i% Xthe inflammation caused by T. gondii by stimulating inflammatory
9 V' r: q! K1 @# }4 c: {. wmonocytes to release prostaglandin E2, which dampens neutrophil activity. The 7 j3 Y4 t1 l/ K2 ]/ g' h; ]+ ^' Q
cover depicts commensal bacteria in blue and intestinal villi in red in mice q" b7 k6 F d. ?
infected with T. gondii. Image credit: Lily Y. Koo and Michael J. Molloy. " Y% g6 w3 O8 c" K
" ?% H- [& q) f Q( G& w" k! d% D/ \ |
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发表于 2013-6-8 20:34
发表于 2013-6-10 15:54
