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Toxoplasma gondii infects the mouse gut and induces / I' D' W# o; Q# M. S+ S
an inflammatory response mediated by neutrophils that damages the intestinal
7 N3 u( ?" {" I* X& h! @/ O% ]4 vtissue and leads to proliferation and translocation of commensal bacteria. In
* R5 N8 i, ]: U/ z- Jthis issue, Grainger et al. report that commensal bacteria help temper
& {1 v% M' F0 C& t$ s' Wthe inflammation caused by T. gondii by stimulating inflammatory 7 T5 N5 ` ?6 H3 n0 J
monocytes to release prostaglandin E2, which dampens neutrophil activity. The
0 W( z3 i, s, p( ncover depicts commensal bacteria in blue and intestinal villi in red in mice + X R: O$ B1 k) G6 s0 O3 ^, ^
infected with T. gondii. Image credit: Lily Y. Koo and Michael J. Molloy.
1 x) c, K1 Y. a, ?! L z7 o' C# z Q2 C2 N+ j' C7 J7 m7 d
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发表于 2013-6-8 20:34
发表于 2013-6-10 15:54
