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' D3 e6 ], e& {* ^# \$ M, CVolume 78, Issue 57 H5 D0 q- C# O: \9 N0 T
On the cover: During brain development, commissural axons cross the midline
! P6 s8 F6 x/ b3 u& yand later elaborate synapses in their target areas. Using a conditional Robo3
6 b, U' J$ `1 L& A& D! z: ^& zknockout approach at the calyx of Held synapse, Michalski et al. (pages 855–868)
: `& C0 C9 P; U j" Breport that axon midline crossing conditions the functional maturation of this
) {5 G0 L$ @+ S, C; Ularge commissural output synapse. In contrast to contralateral calyx of Held
; {) }9 {5 K$ T! A! usynapses in wild-type mice, ipsilateral calyx of Held synapses in Robo3
; e) L/ t' R) s2 @) x5 e% ^) Hconditional knockout (cKO) mice showed strong deficits in synaptic transmission.
/ s& j5 r' T3 w6 KThe aquarelle on the cover depicts the calyx of Held-generating axons and their
1 w E3 Y7 Y+ i7 ~; f/ ]# w3 Qsynapses as flowers. On top, the physiological situation is represented by % l; f$ E m$ k2 W1 v
crossing stems that lead to functional calyx synapses, symbolized by colorful 4 Y. k/ p+ q, I2 {5 l4 @0 R( d
flowers. Below, nonfunctional calyx synapses in Robo3 cKO mice are depicted by 4 Z$ s. Z6 I9 r) Q& x8 g% T
stems unable to cross, leading to fading calyceal flowers. The aquarelle was 9 k8 u: c$ a5 T' R/ e6 U
painted by Nicolas Michalski.! F+ V& z4 o) O+ v$ i. U- r) i
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发表于 2013-6-10 22:08
