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Volume 78, Issue 5
0 X J( d# F& X( z! SOn the cover: During brain development, commissural axons cross the midline : o' d+ K5 ]( w% N) X
and later elaborate synapses in their target areas. Using a conditional Robo3
2 Q, K# `2 I% ~knockout approach at the calyx of Held synapse, Michalski et al. (pages 855–868) / h0 H9 U5 X" G2 l+ g v3 ~- I
report that axon midline crossing conditions the functional maturation of this
a4 u& w- C$ w" k2 Olarge commissural output synapse. In contrast to contralateral calyx of Held
5 K; U7 t8 t% s( I) n4 g8 I0 bsynapses in wild-type mice, ipsilateral calyx of Held synapses in Robo3 6 _& R7 P0 b& l5 d
conditional knockout (cKO) mice showed strong deficits in synaptic transmission.
# \& W3 K( f% D7 q1 N% C6 y7 xThe aquarelle on the cover depicts the calyx of Held-generating axons and their
: W! n9 a8 D7 B5 F! Nsynapses as flowers. On top, the physiological situation is represented by
; B2 J, `: T2 m5 v* }0 ?2 _) `crossing stems that lead to functional calyx synapses, symbolized by colorful 6 R2 y, R: a# @0 E6 d L) ?( ?. l
flowers. Below, nonfunctional calyx synapses in Robo3 cKO mice are depicted by / c8 K7 }1 p/ U; G# A
stems unable to cross, leading to fading calyceal flowers. The aquarelle was 0 K- _5 r( s! f( P5 q# J
painted by Nicolas Michalski.4 x+ y8 W* @- `: n" x
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发表于 2013-6-10 22:08
