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Volume 78, Issue 5( ?/ F9 t/ i: C- {, E( t/ _
On the cover: During brain development, commissural axons cross the midline
9 {6 B$ L1 T( M1 f% {+ @* \and later elaborate synapses in their target areas. Using a conditional Robo3 ; b8 z# C6 r9 F+ ]9 n+ S, R6 F
knockout approach at the calyx of Held synapse, Michalski et al. (pages 855–868) 6 w# c* l% n$ c: K- w X" D
report that axon midline crossing conditions the functional maturation of this
% U& f; \* `# hlarge commissural output synapse. In contrast to contralateral calyx of Held & I/ W" z. h- K4 ^
synapses in wild-type mice, ipsilateral calyx of Held synapses in Robo3 + s4 x. m1 b. ~/ `. r2 {( q
conditional knockout (cKO) mice showed strong deficits in synaptic transmission. 0 G. ]+ M0 E0 t0 m. u
The aquarelle on the cover depicts the calyx of Held-generating axons and their
; t- H% ?9 G' P0 r8 gsynapses as flowers. On top, the physiological situation is represented by ' J, [: L4 ^" _. N, X7 x# v
crossing stems that lead to functional calyx synapses, symbolized by colorful 1 b# X3 B- R6 `7 g- b4 _
flowers. Below, nonfunctional calyx synapses in Robo3 cKO mice are depicted by
+ M( }. b" E. K4 l" I$ w- Istems unable to cross, leading to fading calyceal flowers. The aquarelle was / W9 K- X/ [- C
painted by Nicolas Michalski.
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发表于 2013-6-10 22:08
