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$ C8 _% n- D- b8 C8 A+ ~Volume 78, Issue 5
' |1 x% y! D2 M' j8 n6 E- K% k6 N2 YOn the cover: During brain development, commissural axons cross the midline
4 `2 ?% w* D- n) r' y' A0 }and later elaborate synapses in their target areas. Using a conditional Robo3
" [, r- t( X2 L% Jknockout approach at the calyx of Held synapse, Michalski et al. (pages 855–868)
' Z" y$ c9 u) ~; v) jreport that axon midline crossing conditions the functional maturation of this - M% e5 x/ [. X# W! i) X
large commissural output synapse. In contrast to contralateral calyx of Held
" Q% Q' O: g* l/ J+ [- {synapses in wild-type mice, ipsilateral calyx of Held synapses in Robo3 3 x; D* ]% z- B/ q" g1 ?. p; Y
conditional knockout (cKO) mice showed strong deficits in synaptic transmission. 9 o) P$ U8 _7 G, X0 O6 w' s/ }$ s
The aquarelle on the cover depicts the calyx of Held-generating axons and their
9 c# w* V7 g, m- q- psynapses as flowers. On top, the physiological situation is represented by ) z R3 w5 q: z3 a4 g
crossing stems that lead to functional calyx synapses, symbolized by colorful $ {2 K9 W' ^3 @/ G. _, M
flowers. Below, nonfunctional calyx synapses in Robo3 cKO mice are depicted by 0 }* H& c& ^9 D* O' [+ i/ |- M1 `
stems unable to cross, leading to fading calyceal flowers. The aquarelle was 7 J4 D1 e" p( g% @
painted by Nicolas Michalski.
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发表于 2013-6-10 22:08
