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 / v4 ~, W$ `- n* Y& b. k) J
Volume 78, Issue 51 v( D* P& y% u h
On the cover: During brain development, commissural axons cross the midline
0 |$ u0 K) O, E2 A- ]( H" g) h+ Zand later elaborate synapses in their target areas. Using a conditional Robo3
7 G; J+ O9 ]7 N( X3 Yknockout approach at the calyx of Held synapse, Michalski et al. (pages 855–868) 3 b6 O8 [) M- @6 A
report that axon midline crossing conditions the functional maturation of this
! _# U0 |4 K& ?0 ~$ elarge commissural output synapse. In contrast to contralateral calyx of Held * \) g8 ]1 d/ W$ M7 L6 f, T: C
synapses in wild-type mice, ipsilateral calyx of Held synapses in Robo3 4 k4 z$ B0 I0 A( [
conditional knockout (cKO) mice showed strong deficits in synaptic transmission.
, j; k3 I* E! n& z- ~9 sThe aquarelle on the cover depicts the calyx of Held-generating axons and their ' L2 [' O2 X' m; `
synapses as flowers. On top, the physiological situation is represented by - t5 D7 [4 E7 t
crossing stems that lead to functional calyx synapses, symbolized by colorful
/ ]$ Z$ m8 z1 m$ ~3 Y2 e7 s" r% Oflowers. Below, nonfunctional calyx synapses in Robo3 cKO mice are depicted by
" `1 z' W0 ?; ^6 [( x5 [! Kstems unable to cross, leading to fading calyceal flowers. The aquarelle was 2 N; Y' C- u% l3 q0 S4 O& s+ e% j: z
painted by Nicolas Michalski.
, O# L1 a+ v7 h0 t! @ |
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发表于 2013-6-10 22:08
