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Volume 78, Issue 5
9 A; Q! K# y' GOn the cover: During brain development, commissural axons cross the midline
/ w1 J' e9 {1 {) fand later elaborate synapses in their target areas. Using a conditional Robo3 ' {$ Q. K& s0 m: I- e6 w( n) p$ K
knockout approach at the calyx of Held synapse, Michalski et al. (pages 855–868) ; _! B9 R# m1 \, U& M/ q) Z
report that axon midline crossing conditions the functional maturation of this
5 e' l( W) r/ N9 o+ _large commissural output synapse. In contrast to contralateral calyx of Held ' `! K6 I* M! Y. q
synapses in wild-type mice, ipsilateral calyx of Held synapses in Robo3
; y M1 F5 y5 D! V( o( sconditional knockout (cKO) mice showed strong deficits in synaptic transmission. - C! I, C# F0 R# z
The aquarelle on the cover depicts the calyx of Held-generating axons and their
9 v% i2 `0 `3 j8 B! j V' h. |: Bsynapses as flowers. On top, the physiological situation is represented by & i, K4 @, f8 Y! C c/ R q* t+ u
crossing stems that lead to functional calyx synapses, symbolized by colorful
$ ]9 T8 g$ m" l* J$ R" dflowers. Below, nonfunctional calyx synapses in Robo3 cKO mice are depicted by * G" i. C" t( w. a) l% |: ^
stems unable to cross, leading to fading calyceal flowers. The aquarelle was
% ~( ]% g2 F# a' b% Apainted by Nicolas Michalski.
8 z1 @. V5 d; l |
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发表于 2013-6-10 22:08
