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: B) r. k, p9 t: u% h/ w& IVolume 78, Issue 59 ~! [9 |) [! L% q. E/ V3 h
On the cover: During brain development, commissural axons cross the midline 8 s8 z- e9 r$ B6 T
and later elaborate synapses in their target areas. Using a conditional Robo3 9 o ?0 ~. {0 W' G
knockout approach at the calyx of Held synapse, Michalski et al. (pages 855–868)
$ x. o& N8 [# p* Wreport that axon midline crossing conditions the functional maturation of this 7 O) c" B& n! P l5 i
large commissural output synapse. In contrast to contralateral calyx of Held
0 q% j5 n( Y0 Y5 s( J% isynapses in wild-type mice, ipsilateral calyx of Held synapses in Robo3 * ?7 i( \4 q, P# d/ G6 ~
conditional knockout (cKO) mice showed strong deficits in synaptic transmission. 2 P" F1 l" v, N3 B
The aquarelle on the cover depicts the calyx of Held-generating axons and their
, A- w* M' @# ]- { w( f, o# Tsynapses as flowers. On top, the physiological situation is represented by
) E$ u3 J" X" mcrossing stems that lead to functional calyx synapses, symbolized by colorful " M$ h F7 K7 f! e/ |* U ]! B' q8 c
flowers. Below, nonfunctional calyx synapses in Robo3 cKO mice are depicted by
& ~6 T9 F! E. P2 N$ H. _/ B* A8 pstems unable to cross, leading to fading calyceal flowers. The aquarelle was ; O( C+ Q1 e, \9 g8 D
painted by Nicolas Michalski.% J. ^. B, o2 B2 g
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发表于 2013-6-10 22:08
