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 & V K7 A2 X Q+ j7 O' F
Volume 38, Issue 61 h5 q F; Y& O. o/ Z
On the cover: Satoh et al. (1105–1115) demonstrate that a genome organizer,
& x q8 x5 U6 ?+ \& v2 l9 x, A6 r6 Ispecial AT-rich sequence binding protein 1 (Satb1), is important in " a) b M1 G& |* U9 P
lymphoid-lineage specification of hematopoietic stem cells (HSCs). The cover
0 K5 \1 U" e; b% jimage shows that the attenuation of Satb1 expression in aged HSCs results in 6 w* z8 K& \1 {( X& V- x: x* C7 C2 [
reduced lymphopoietic potential, which is one of the manifestations of 3 f! m0 P0 ]8 v
“immunosenescence.” Their findings suggest that Satb1 expression is a useful & Z- U* P! t/ t# R* X
biomarker of aging and could be manipulated to reverse immunosenescence. “M,”
3 i" _, U3 v: F8 j1 {“E,” and “L” indicate “myeloid-,” “erythroid-,” and “lymphoid-fate decisions,”
' _$ a5 w$ K! Q3 j2 rrespectively. Image by Yusuke Satoh and Yusuke Koshima. d. J/ G8 e& A5 w
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发表于 2013-6-28 22:55
发表于 2013-6-29 07:47
