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- 积分
- 17983
- 威望
- 17983
- 包包
- 26159
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1 K" o$ R5 Z& e4 _5 ^2 d1 NVolume 38, Issue 6
6 z' f5 j! p1 z) H* B" o: W1 K- `% NOn the cover: Satoh et al. (1105–1115) demonstrate that a genome organizer, 9 w4 T" u' S" I* L
special AT-rich sequence binding protein 1 (Satb1), is important in ' y% V) k5 Y3 n# u# t7 V: H
lymphoid-lineage specification of hematopoietic stem cells (HSCs). The cover
- w; ?& e, E) [- ^5 Wimage shows that the attenuation of Satb1 expression in aged HSCs results in 5 ]( B z% s2 @4 j% W9 I1 n
reduced lymphopoietic potential, which is one of the manifestations of : ~' @: X' z% m' Z: s( `& |
“immunosenescence.” Their findings suggest that Satb1 expression is a useful " b! H% n$ `5 ]3 R' A) t+ @
biomarker of aging and could be manipulated to reverse immunosenescence. “M,”
4 n5 M$ w" l: u4 Z+ b“E,” and “L” indicate “myeloid-,” “erythroid-,” and “lymphoid-fate decisions,” . y. [& V* U8 ?% q4 a) |
respectively. Image by Yusuke Satoh and Yusuke Koshima.& h2 e& o0 x3 v. d
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发表于 2013-6-28 22:55
发表于 2013-6-29 07:47
