文献求助 JCI

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http://www.jci.org/articles/view/64095
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" \2 Y! h# t+ J; c+ yThe role of aging upon β cell turnover/ K2 G8 X! e! Y5 u! g4 n7 M
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Jake A. Kushner3 l) i8 i  W3 r7 B1 }7 _. k# Q" v% C

* v( M4 x1 f+ h" a# h/ L. c/ o; H% oPublished March 1, 2013
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Preservation and regeneration of β cell endocrine function is a long-sought goal in diabetes research. Defective insulin secretion from β cells underlies both type 1 and type 2 diabetes, thus fueling considerable interest in molecules capable of rebuilding β cell secretion capacity. Though early work in rodents suggested that regeneration might be possible, recent studies have revealed that aging powerfully restricts cell cycle entry of β cells, which may limit regeneration capacity. Consequently, aging has emerged as an enigmatic challenge that might limit β cell regeneration therapies. This Review summarizes recent data regarding the role of aging in β cell regeneration and proposes models explaining these phenomena.

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