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http://www.jci.org/articles/view/64095
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+ v4 A8 i: t& e+ I$ H" o9 D! B8 Z) G4 GThe role of aging upon β cell turnover
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  X1 f" k/ y7 B2 G& H5 D1 n* JJake A. Kushner; Y. p  @; S) L. b0 q& g

  X6 j" V8 |; s1 n# s* SPublished March 1, 2013/ U1 F4 f: z! T# e

. W! J3 c. `. \" K8 z1 vPreservation and regeneration of β cell endocrine function is a long-sought goal in diabetes research. Defective insulin secretion from β cells underlies both type 1 and type 2 diabetes, thus fueling considerable interest in molecules capable of rebuilding β cell secretion capacity. Though early work in rodents suggested that regeneration might be possible, recent studies have revealed that aging powerfully restricts cell cycle entry of β cells, which may limit regeneration capacity. Consequently, aging has emerged as an enigmatic challenge that might limit β cell regeneration therapies. This Review summarizes recent data regarding the role of aging in β cell regeneration and proposes models explaining these phenomena.