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http://www.jci.org/articles/view/64095
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The role of aging upon β cell turnover
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. U  K: ^8 C4 m/ \1 ]' M5 vJake A. Kushner* t1 G) B( X" s. o+ T! t

( V. b0 f' A% T" aPublished March 1, 2013+ A- a4 w& U7 J( i& |

; y/ ^* u" X. r- @7 Q0 MPreservation and regeneration of β cell endocrine function is a long-sought goal in diabetes research. Defective insulin secretion from β cells underlies both type 1 and type 2 diabetes, thus fueling considerable interest in molecules capable of rebuilding β cell secretion capacity. Though early work in rodents suggested that regeneration might be possible, recent studies have revealed that aging powerfully restricts cell cycle entry of β cells, which may limit regeneration capacity. Consequently, aging has emerged as an enigmatic challenge that might limit β cell regeneration therapies. This Review summarizes recent data regarding the role of aging in β cell regeneration and proposes models explaining these phenomena.

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