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http://www.jci.org/articles/view/64095/ C8 T5 K- u" R1 @3 C( ]* n7 l
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The role of aging upon β cell turnover
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Jake A. Kushner) S% x" i3 r9 p! u3 {0 b

' W% H) a; v! x3 M% I+ wPublished March 1, 2013' W8 H5 K" x5 U# K

5 ?( \; a6 b* F/ g2 jPreservation and regeneration of β cell endocrine function is a long-sought goal in diabetes research. Defective insulin secretion from β cells underlies both type 1 and type 2 diabetes, thus fueling considerable interest in molecules capable of rebuilding β cell secretion capacity. Though early work in rodents suggested that regeneration might be possible, recent studies have revealed that aging powerfully restricts cell cycle entry of β cells, which may limit regeneration capacity. Consequently, aging has emerged as an enigmatic challenge that might limit β cell regeneration therapies. This Review summarizes recent data regarding the role of aging in β cell regeneration and proposes models explaining these phenomena.

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