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http://www.jci.org/articles/view/64095
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. t" E+ U5 h$ l% o. l1 xThe role of aging upon β cell turnover
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Jake A. Kushner
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5 E1 d$ \9 O6 A* S0 k  HPublished March 1, 2013. a6 U. s7 I6 Q- l

4 B' K5 {/ f* _$ g4 O  v3 \* ePreservation and regeneration of β cell endocrine function is a long-sought goal in diabetes research. Defective insulin secretion from β cells underlies both type 1 and type 2 diabetes, thus fueling considerable interest in molecules capable of rebuilding β cell secretion capacity. Though early work in rodents suggested that regeneration might be possible, recent studies have revealed that aging powerfully restricts cell cycle entry of β cells, which may limit regeneration capacity. Consequently, aging has emerged as an enigmatic challenge that might limit β cell regeneration therapies. This Review summarizes recent data regarding the role of aging in β cell regeneration and proposes models explaining these phenomena.

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