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2013-7-26 Science
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COVER Immunostained fluorescence microscopy image of memory 8 B% J& P; R" d1 _3 c) `1 C
engram–bearing cells (red) in the dentate gyrus of a mouse hippocampus (image
0 X4 k( b8 o5 Q8 N( `4 Kwidth: 1.5 millimeters). These cells were genetically tricked to express the
8 l# `6 x: _4 b6 [5 l3 [8 V) k n& `protein channelrhodopsin-2 during memory formation, thus becoming responsive to
$ w! r. x# |# ^light stimulation. When the cells were activated by light, the mice
- J( q) L& H/ l+ l( b' |: h3 _simultaneously associated a genuine memory with an undesirable event (a foot ' a7 Q/ w5 v+ d* p1 d. T
shock) to create a new but false memory. See page 387. Image:
2 l8 c# q& V5 s8 z- `0 ZXu Liu and Steve Ramirez * ]6 [/ u, n$ X: b: _" _
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